Application Notes
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Pathway Studio software for Gene Expression Analysis |
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Pathway Analysis of Lung Emphysema Gene Expression Profiles * |
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Microglia regulatory network * |
Pathway Studio software for Gene Expression AnalysisMicroarray gene expression data represents a snapshot in time of the RNA population under investigation. The measurement itself does not weigh transcription or RNA degradation or even if specific mRNAs are translated. Using Signaling Line Pathways and Gene Set Enrichment Analysis Pathway Studio offers an approach to interpret microarray data through “guilt by association” and identify the cellular processes affected in the experiment.Open [2 Mb ] |
Pathway Analysis of Lung Emphysema Gene Expression ProfilesDescribes approaches on how to gain understanding of disease mechanism by analysing patients microarray expression data in Pathway Studio.* Open [870 Kb ] |
Microglia regulatory networkThe use case based on the paper "The microglial gene regulatory network activated by interferon-gamma", J Neuroimmunol. 2006 Dec 21.* Open [162 Kb ] |
Published Application Notes
Pathway studio - the analysis and navigation of molecular networks
Alexander Nikitin, Sergei Egorov, Nikolai Daraselia and Ilya Mazo
Bioinformatics 2003, v.19(16):2155-2157
Pathway Analysis in Drug Development
Azat Badretdinov, Anton Yuryev
Pharma & Bio Ingredients March 2006
Targeting transcription factors in cell regulation
Anton Yuryev
Expert Opinion on Therapeutic Targets
Pathway analysis software as a tool for drug target selection, prioritization and validation of drug mechanism
Sivachenko A & Yuryev A
Expert Opinion on Therapeutic Targets, v.11(3), pp.411-421
