Notch Pathway

Notch Pathway has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. atonal --+> microtubule cytoskeleton assembly rps6k ---> chromatin remodeling ubiquitin-dependent protein degradation actin-based cytoskeleton assembly triacylglycerols degradation intermediate filament polymerization microtubule cytoskeleton assembly ecm proteins lipid transport mapkapk ---> aromatic aminoacid metabolism aromatic aminoacid metabolism telomere maintenance chromatin remodeling glucose metabolism shc --+> grb shc --+> src sos erk1/3 ---| intermediate filament polymerization rps6k ---> actin-based cytoskeleton assembly mek1/2 --+> erk1/3 srf src ubiquitous bhlh-zip factors --+> triacylglycerols degradation erk1/3 --+> mapkapk rock1/2 --+> limk dusp ---| erk1/3 src --+> raf dvl mdia ---> actin-based cytoskeleton assembly ubiquitous bhlh-zip factors ---> glucose metabolism atonal mapkapk dll notch --+> rbpj erk1/3 --+> myc/mad/max myc/mad/max --+> ubiquitin-dependent protein degradation ubiquitous bhlh-zip factors mek1/2 dlli erk1/3 --+> rps6k sos --+> ras mdia raf mlcp myc/mad/max --+> telomere maintenance myc/mad/max --+> chromatin remodeling rock1/2 ---> actin-based cytoskeleton assembly myc/mad/max erk1/3 --+> srf rock1/2 ---| mlcp rho --+> mdia src --+> shc ras mapkapk ---> actin-based cytoskeleton assembly dlli ---| notch dusp rho notch rho-gap ---| rho limk ---> actin-based cytoskeleton assembly dvl ---| notch notch --+> src rock1/2 grb --+> sos srf --+> jun/fos rho-gap rbpj --+> hairy, hairy/e(spl) erk1/3 dll --+> notch jun/fos mkp hairy, hairy/e(spl) ---| atonal mapkapk --+> srf src --+> rho-gap limk rps6k jun/fos ---> ecm proteins erk1/3 --+> ubiquitous bhlh-zip factors rho --+> rock1/2 raf --+> mek1/2 hairy, hairy/e(spl) rbpj shc src ---> actin-based cytoskeleton assembly grb ubiquitous bhlh-zip factors --+> lipid transport ubiquitous bhlh-zip factors --+> aromatic aminoacid metabolism mkp ---| erk1/3 ras --+> raf rock1/2 ---> intermediate filament polymerization mlcp ---| actin-based cytoskeleton assembly Notch Pathway pathway