NK Cell Activation pathway

NK Cell Activation pathway has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. camk ---> vesicular secretory pathway (golgi -> membrane}) vesicular secretory pathway (golgi -> membrane}) nf-at --+> tnf family fak --+> src dap10 --+> grb plc; dag; ip3 sos tetraspanin sp camkk calcineurin ca2+ --+> calcineurin erk1/3 --+> ets mek1/2 --+> erk1/3 shp2 --+> grb ankcr ---- nkcr dap12 --+> syk nkcr dap12 calmodulin --+> calcineurin plc src erk1/3 --+> sp erk1/3 --+> mapkapk inkcr ---- nkcr src --+> raf ncr ras-grf dusp ---| erk1/3 itpr rac/cdc-gef --+> rac/cdc42 pak --+> raf mapkapk itpr --+> ca2+ sos --+> ras shc --+> grb creb --+> cytokine syk --+> lat pkc pi3k --+> pip3 dag pp2a mek1/2 camkk --+> camk pak --+> rac/cdc-gef ras-grf --+> ras cbl ---| syk syk --+> shc syk --+> plc cd3z --+> syk shp1 shp2 egr/krox pip3 --+> vav itg csk calmodulin raf ets --+> cytokine shc --+> plc mapkapk --+> creb src --+> plc rac/cdc-gap ca2+ --+> pkc ca2+ --+> ras-grf sp --+> cytokine fak --+> shc shp1 ---| syk inkcr rac/cdc-gef ras lat src --+> shc ets creb --+> tnf family pak --+> mek1/2 src --+> pi3k dap10 --+> pi3k egr/krox --+> cytokine ankcr pi3k --+> plc dusp fak src --+> vav lat --+> grb pten ---| pip3 calmodulin --+> camkk grb --+> sos ncr --+> cd3z rac/cdc42 rac/cdc-gap ---| rac/cdc42 dag --+> pkc itpk camk ets --+> tnf family erk1/3 ---> nf-at ca2+ --+> calmodulin csk ---| src pak slp76 itpk ---> ip3 nf-at syk --+> slp76 sp --+> tnf family inkcr --+> shp2 inkcr --+> shp1 slp76 --+> vav syk erk1/3 tnf family pp2a ---| pkc mkp pi3k ip3 egr/krox --+> tnf family vav --+> rac/cdc42 rac/cdc42 --+> pak src --+> fak cytokine ip3 --+> itpr pten pkc --+> ras nf-at --+> cytokine raf --+> mek1/2 pkc --+> raf lat --+> plc fak --+> pi3k dap10 --+> plc ankcr --+> dap12 fcer --+> cd3z dap10 cbl vav calmodulin --+> itpk ca2+ syk --+> cbl cbl ---| src ankcr --+> dap10 itg ---- tetraspanin cd3z shc shc --+> src itg --+> src nf-at --+> egr/krox fcer grb itg --+> fak calcineurin --+> nf-at ras --+> raf itgl --+> itg src --+> syk fak ---- grb creb mkp ---| erk1/3 ca2+ --+> fak pip3 itgl syk --+> vav NK Cell Activation pathway