Insulin Signaling Pathway

Insulin Signaling Pathway has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. pi3k --+> pip3 pip3 --+> pdpk1 camp --+> pka adcy --+> camp p70s6k ---> translation ets ---- srf rps6k ---> translation mnk1/2 ---> translation sp ---> glucose import pka ---| glycogen synthesis pka ---> pentose-phosphate shunt ampk --+> glucose import pdx ---> glucose metabolism ubiquitous bhlh-zip factors --+> lipid transport c/ebp ---> glucose metabolism hnf4-like ---> glucose metabolism pentose-phosphate shunt glycogen synthesis endocytosis tricarboxylic acid cycle triacylglycerols degradation fatty acid oxidation lipid transport forkhead --+> glucose import glucose import translation glucose metabolism fatty acid biosynthesis sp pdpk1 --+> akt adcy sos c/ebp ---> tricarboxylic acid cycle ampk ---| fatty acid biosynthesis erk1/3 --+> ets srf mek1/2 --+> erk1/3 rps6k --+> ets socs ---| irs dusp ---| erk1/3 erk1/3 --+> sp mnk1/2 ubiquitous bhlh-zip factors --+> triacylglycerols degradation pka --+> sp akt ---> sp camp pdpk1 socs insr phosphatase ubiquitous bhlh-zip factors ---> glucose metabolism igfbp ---| insulin pp2a ubiquitous bhlh-zip factors erk1/3 --+> mnk1/2 sos --+> ras irs --+> grb irs --+> pi3k pkc mek1/2 insr forkhead ---> glucose metabolism erk1/3 --+> rps6k p70s6k pkc ---> ubiquitous bhlh-zip factors raf pkc ---> endocytosis rps6k ---> c/ebp irs erk1/3 --+> srf ets ras igfbp dusp pkc --+> translation akt ---| camp ampk --+> fatty acid oxidation forkhead hnf4-like pten ---| pip3 insulin --+> insr ampk ---| hnf4-like pkc ---> pdx akt --+> mtor grb --+> sos gsk3 akt ---| forkhead erk1/3 --+> c/ebp ampk --+> tsc mkp pp2a ---| pkc erk1/3 pi3k tsc ---| mtor c/ebp ---> fatty acid oxidation gsk3 ---| glycogen synthesis akt --+> ets rps6k pten erk1/3 --+> ubiquitous bhlh-zip factors pdx raf --+> mek1/2 pkc --+> raf pkc --+> ras insr phosphatase ---| insr c/ebp pka mtor c/ebp --+> glucose import hnf4-like --+> lipid transport akt ---| tsc ras --+> pi3k tsc akt erk1/3 ---| hnf4-like insr phosphatase ---| irs insr --+> irs ampk grb insulin ampk ---> glucose metabolism pka ---> tricarboxylic acid cycle mtor --+> p70s6k mkp ---| erk1/3 akt ---| gsk3 ras --+> raf pip3 pka --+> triacylglycerols degradation pp2a --+> p70s6k ubiquitous bhlh-zip factors --+> fatty acid biosynthesis Insulin Signaling Pathway pathway