IL-6 signaling via MAPK cascade

IL-6 signaling via MAPK cascade has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. il6 sos1 map2k1 --+> mapk3 il6st --+> jak2 map2k2 --+> mapk1 elk1 mapk3 --+> elk1 raf1 --+> map2k1 srf mapkapk2 --+> srf grb2 elk4 mapk3 --+> elk4 map2k1 mapkapk2 il6 --+> il6r sos1 --+> ras map2k2 ras elk4 ---- srf mapk1 --+> mapkapk2 il6r ---- il6st raf1 --+> map2k2 map2k2 --+> mapk3 ptpn11 --+> grb2 map2k1 --+> mapk1 elk1 ---- srf mapk1 --+> elk1 mapk1 --+> cebpb grb2 --+> sos1 jak2 il6r jak2 --+> ptpn11 ras --+> raf1 ptpn11 mapk1 cebpb mapk3 il6st mapk3 --+> mapkapk2 raf1 IL-6 signaling via MAPK cascade pathway