IGF receptor signaling via MAPK cascade

IGF receptor signaling via MAPK cascade has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. sos1 map2k1 --+> mapk3 srebf1 ins map2k2 --+> mapk1 elk1 mapk3 --+> elk1 mapk3 --+> srebf1 raf1 --+> map2k1 srf mapkapk2 --+> srf ins --+> igf1r irs1 --+> grb2 igf1 grb2 elk4 mapk1 --+> myc irs1 src src --+> raf1 mapk3 --+> elk4 igf1r --+> irs1 gb/g --+> src map2k1 mapkapk2 sos1 --+> ras igf1r --+> shc1 elk4 ---- srf ras map2k2 hif1a mapk1 --+> mapkapk2 mapk3 --+> hif1a raf1 --+> map2k2 map2k2 --+> mapk3 shc1 --+> grb2 igf1r --+> gb/g elk1 ---- srf map2k1 --+> mapk1 mapk1 --+> elk1 mapk1 --+> srebf1 grb2 --+> sos1 igf1r igf2 gb/g myc mapk3 --+> myc igf2 --+> igf1r ras --+> raf1 mapk1 shc1 mapk3 igf1 --+> igf1r mapk3 --+> mapkapk2 raf1 mapk1 --+> hif1a IGF receptor signaling via MAPK cascade pathway