Axon Guidance

Axon Guidance pathway has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. mapkapk ---> actin-based cytoskeleton assembly fak --+> actin-based cytoskeleton assembly polymerase ii transcription telomere maintenance intermediate filament polymerization erk1/3 ---> dna repair dna repair phospholipid scrambling actin-based cytoskeleton assembly mkp ---| erk1/3 calcineurin --+> nf-at mlck chemokine itgl itgl --+> itg mlcp ---| actin-based cytoskeleton assembly ras --+> raf camp --+> pka abl ---| telomere maintenance abl ---> polymerase ii transcription gi/o ---| adcy ephrinr --+> abl roboi rho-gef --+> rho itg --+> fak dcc --+> rac/cdc42 nf-at --+> egr/krox abl --+> map3k raf --+> mek1/2 rho --+> rock1/2 nrp ---- plx pka ca2+ ngef ngef --+> rho roboi ---| robo rac/cdc42 --+> pak limk dcc rps6k ephrinr --+> ngef egr/krox ---| ca++ export mkp raf --+> map3k calmodulin --+> mlck gi/o sema netrin erk1/3 abl ---> phospholipid scrambling erk1/3 ---> nf-at abl nf-at gicr pak ca2+ --+> calmodulin plx --+> rho-gef robo --+> rac/cdc-gap chemokine --+> gicr pp5/2cb ---| map3k pka ---> actin-based cytoskeleton assembly limk ---> actin-based cytoskeleton assembly rock1/2 rac/cdc42 rac/cdc-gap ---| rac/cdc42 netrin ---| unc ephrinr --+> ras-gap dusp pak --+> map3k pak --+> mek1/2 rac/cdc42 --+> map3k rho fak pak ---| mlck rho --+> mdia ras rac/cdc-gef rho-gef slit rho --+> map3k rock1/2 ---| mlcp rho ---| rac/cdc42 rac/cdc-gap nrp ras-gap map3k ca2+ --+> ras-grf dcc ---> fak dcc --+> ca2+ pak --+> limk ras-grf --+> ras robo egr/krox raf mlcp ephrin itg calmodulin ephrin --+> ephrinr pak --+> rac/cdc-gef map3k --+> mek1/2 adcy --+> camp mdia unc mek1/2 ephrinr sema --+> nrp erk1/3 --+> rps6k dcc ---| rho dcc ---- unc mapkapk pp5/2cb camp abl ---| dna repair mdia ---> actin-based cytoskeleton assembly dusp ---| erk1/3 ras-gap ---| ras netrin --+> dcc ras-grf sema --+> plx rac/cdc-gef --+> rac/cdc42 pka ---> intermediate filament polymerization erk1/3 --+> mapkapk mek1/2 --+> erk1/3 calmodulin --+> calcineurin plx slit --+> robo rps6k ---> actin-based cytoskeleton assembly calcineurin adcy fak --+> rho-gef gicr --+> gi/o ca2+ --+> calcineurin erk1/3 ---| intermediate filament polymerization ca++ export actomyosin based movement mlck ---> actomyosin based movement Axon Guidance pathway