Apoptosis Regulation Pathway

Apoptosis regulation pathway has been created using Ariadne's Pathway Studio and ResNet Database of over 1.5 Million molecular interactions and functional relationships. The pathway diagram is interactive: click on entities and relations to retrieve additional information and literature references. You can check the meaning of different shapes and colors using the Legend.

ariadne genomics inc. neurexin cadpr --+> ryr naadp --+> ca2+ naadp cadpr non-voltage ca++ import --+> ca2+ non-voltage ca++ import tgfbr tirap nf-kb --+> iap camp --+> pka tnfrap --+> casp8/10 tirap --+> tnfrap ngf family bid pip3 ismad ---| smad ngf family --+> ngfr ngfr ---- ntrk il1 family --+> il1r sh2b bcl shp1 ---| jak akt --+> ikbk pip3 --+> pdpk1 nogo --+> nogor tgfbr --+> smad il1 family nxph cytc akt tnfrap --+> map3k il1rl1 ---| tlr il1rl1 il1i pka ca2+ casp3/6/7 diablo ---| iap p53 --+> bid il1rd casp8/10 cytokine pten tnfrap ngf family --+> ntrk tnf family il1rl1 ---| il1r pi3k pka ---| bid calmodulin --+> adcy jak --+> pi3k ca2+ --+> calmodulin il1rd ---| il1r mdm2/4 nik --+> ikbk pp5/2cb ---| map3k iap sh2b --+> jak tgf family smad stc ---| voltage-dependent ca++ import flip bid --+> cytc tnfrap --+> nik nik il1 family ---- il1rd calmodulin --+> camkk pten ---| pip3 smad --+> bid atm/atr --+> p53 nfkbi ---| nf-kb ikbk ---| nfkbi calcineurin --+> bid ntrk stc atm/atr voltage-dependent ca++ import --+> ca2+ casp9 casp12 --+> casp3/6/7 tnfr --+> tnfrap iap ---| casp9 cytokiner --+> jak tnf family --+> tnfr map3k nf-kb apaf1 jak diablo flip ---| tnfrap iap ---| casp3/6/7 apaf1 --+> casp9 cd38; naadp; cadpr ryr calmodulin shp1 il1r --+> tirap tirap --+> ikbk cytc --+> apaf1 adcy --+> camp pi3k --+> pip3 neurexin --+> voltage-dependent ca++ import cd38 nfkbi ryr --+> ca2+ casp12 pdpk1 casp9 --+> casp3/6/7 ngfr ---- nogor tlr camp ikbk nogor --+> tnfrap tlr --+> tirap bcl ---| cytc pp5/2cb nogor camkk --+> akt neurexin ---> nxph il1i ---| il1r tnfr p53 cytokiner tgf family --+> tgfbr bcl ---| p53 casp8/10 --+> bid akt ---| bid ntrk --+> sh2b ngfr nf-kb --+> bcl mdm2/4 ---| p53 smad --+> bcl pdpk1 --+> akt cytokine --+> cytokiner il1r nogo adcy camkk calcineurin ngfr --+> tnfrap ca2+ --+> calcineurin map3k --+> nik ismad tgfi tgfi ---| tgf family voltage-dependent ca++ import dna repair cleavage of lamina in apoptosis dna degradation casp3/6/7 ---| dna repair casp3/6/7 --+> cleavage of lamina in apoptosis casp3/6/7 --+> dna degradation nf-kb --+> dna repair smad ---| dna repair p53 ---> dna repair casp8/10 --+> casp3/6/7 Apoptosis Regulation Pathway pathway