The Ariadne Technical Support team receives requests for databases for organisms and research areas not necessarily covered by the ResNet Mammalian and Plant databases. As a result, Ariadne has built the following "Targeted Databases" data sets and makes these available on an "as is" basis as seed data sets for interested researchers. ResNet Targeted Databases containing pathways and functional relations are available for three model organisms: Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster. (The previously available Arabidopsis thaliana model data set is now incorporated and forms part of the ResNet Plant Database release.)

All databases contain protein annotations from EntrezGene and can be used for the analysis of gene expression data. The orthologous interactions can be exchanged among different databases to enrich their content. The orthologs between model organisms have been determined using methods described in Protein annotation and orthologous mapping for ResNet.

Additional molecular interaction databases are also available on an "as is" basis.

• Bos taurus (cow)
• Canis familiaris (dog)
• Gallus gallus (chicken)
• Xenopus laevis (African clawed frog)
• Danio rerio (zebrafish)

These databases were constructed by importing orthologous protein-protein interactions from the ResNet Mammalian Database. A molecular interaction database for Apis mellifera (bee) was constructed using orthologous interactions from the Drosophila database.