DiseaseFx™ is a powerful new informatics resource from Ariadne to help you produce solid results from the plethora of clinical research data and to support new discoveries, develop hypotheses, and create disease-specific mechanistic models.  DiseaseFx supports in-house in silico biomarker discovery programs and pathway analysis of clinical and experimental data.

DiseaseFx is a database derived from peer-reviewed research findings that link human disease with molecular observations such as:

• Changes in the activity of proteins,
• Changes in gene expression,
• Changes in concentration of metabolites, 
• Gene mutations and deletions,
• Changes in epigenetic methylation observed in disease, and
• Explicit reference of genes, proteins, and metabolites as prognostic and diagnostic biomarkers.

DiseaseFx brings together pieces of knowledge and allows you to access and evaluate all available data at the same time.  DiseaseFx serves as both a reference and a discovery tool, allowing you to take a step beyond what’s already known towards new discoveries, hypotheses and disease-specific mechanistic models.

DiseaseFx additionally links diseases with information from ClinicalTrials.gov to enable researchers to smoothly transition from molecular observations to disease and potential therapies. DiseaseFx integrates explicit references from clinical research regarding confirmed and potential prognostic and diagnostic biomarkers.  DiseaseFx can provide a good first approach to determine the specificity of a particular protein as a disease biomarker and provides insights into design of clinical trials.  DiseaseFx provides decision support for prioritizing proteins that are involved in disease pathogenesis, or that are most specific for prognostic or diagnostic applications.

DiseaseFx includes a set of nearly 400 expertly designed “Expression Target” signaling pathways that augment the pathway libraries included with Pathway Studio, allowing deeper insights into disease mechanism and biomarker discovery.  Ariadne designed these pathways based on observations linking cell surface receptors to proteins downstream of transcription factors to produce superior analytical results in the interpretation of experimental profiling  data.

Produced by Ariadne’s proprietary MedScan knowledge-extraction technology, DiseaseFx provides a comprehensive scope of the state of knowledge in an integrated framework, and includes software that allows you to extract additional knowledge from newly published papers, as well as your internal documentation. You can update DiseaseFx in Pathway Studio as frequently as daily to extract facts from additional unstructured data to augment or to capture knowledge from emerging publications, focused on your research.

The disease-centric design of DiseaseFx is designed to integrate with Ariadne’s protein-centric ResNet® Mammalian database, and is synergistic when combined with Ariadne’s compound-centric ChemEffect® database.  Combined, all three databases deliver a highly-accurate and comprehensive resource.

To learn more, please select product collateral to download and review.  Registration may be required.

 Please register to evaluate Pathway Studio; you can also attend our weekly web demonstrations to learn more.

With all other questions, call our sales department at (1-240) 453-6272, or (866) 340-5040 (toll free for USA and Canada). You can also fill-in the Inquiry form, and our sales representative will contact you.