The ChemEffect knowledgebase links published information on small molecules, chemicals, and approved drugs to their effects on biological systems, such as proteins, pathways, and cellular processes.  This information helps scientists profile their drug candidates against known side effects by toxicity and compound type, find metabolizing enzymes, determine associations between toxicities and drug mechanism of action, and seek alternative indications.

ChemEffect comes with MedScan® text mining module that helps extract information from your internal text libraries to augment the database.

Pathway Studio® combined with ChemEffect contains over 1.8 million biological interactions and relationships derived from published research and serves as a powerful investigative tool that advances discovery through interactive, interpretative pathways. Applications include:

• Developing mechanism of toxicity or drug action hypotheses,
• Identifying potential alternative drug indications,
• Correlating drug action with potential side effects, and
• Deducing drug-drug interactions.
  

With ChemEffect, detailed queries and address issues including those listed below can be completed quickly:

• Identifying alternative diseases linked to pathways associated with drug candidates,
• Finding compounds affecting target pathway(s) or proteins,
• Finding protein targets affected by compounds similar to onesthose under your investigation,
• Surveying known side effects associated with compounds, and
• Building hypothetical associations between a compound and its potential outcomes such as efficacy, toxicity and drug-drug interaction.

• Over 122,00 entities:
  • 110,00+ proteins
  • 19,000+ small molecules
  • 2,800+ cellular processes
  • 2,410 diseases
• 1.8 million relations for:
  • Direct and indirect regulation
  • Expression regulation
  • Molecular transport and synthesis
  • Binding
  • Protein modification
  • Metabolization
• Pathways:
  • 227 Receptor signaling pathways
  • 21 cellular process regulation pathways
  • Atlas of Signaling - all cellular signaling on one map
• Ontologies:
  • Gene Ontology
  • Ariadne protein ontology
• Annotations:
• Entrez Gene protein annotations
• Small Molecule attributes (aliases, PubChem Identifiers, and CAS registry numbers)
• Protein annotations (aliases, GO annotation, protein cell localization, and database references) from Dana-Farber Cancer Institute and Harvard School of Public Health
• MedScan dictionary annotations for cell processes and diseases

ResNet Mammalian database includes Ariadne’s proprietary protein ontology which optimizes the analysis results by organizing genes with well-defined cellular and molecular characterizations into a flattened concise ontology. Ariadne additionally provides curated signaling and cellular process regulation pathway collection which can be used for reference, or as components to develop your own disease or mechanistic models.

You can build upon Ariadne’s pathways with Pathway Studio Software tools using data from ResNet and ChemEffect databases, or by adding information from recently published or internal texts and experimental data using MedScan Technology.

 Please register to evaluate Pathway Studio; you can also attend our weekly web demonstrations to learn more.

With all other questions, call our sales department at (1-240) 453-6272, or (866) 340-5040 (toll free for USA and Canada). You can also fill-in the Inquiry form, and our sales representative will contact you.