ResNet® Plant is the premier pathway and protein interaction knowledgebase that, along with Pathway Studio® software, supports plant researchers.  Users obtain access to ResNet Plant as part of their Pathway Studio subscription.  Ariadne has built ResNet Plant based on the well studied model organism, Arabidopsis thaliana.

The knowledgebase includes gene and protein definitions specific for Arabidophsis as well as entity definitions for small molecules, protein complexes, functional classes of enzymes, plant diseases, cellular treatments, and cellular processes.  Each of these entities is identified by a unique, standards based reference such as an EntrezGene ID, InChiKey, MeSH Header, etc.  The definitions include live links to various reference sources including NCBI, TAIR, Unigene, EMBL, BRENDA, ChemIDPlus (NLM), PubChem, and so forth.

The heart of the ResNet Plant database is the vast collection of biological relationships, recovered by Ariadne MedScan® Technology, from peer reviewed, plant specific, scientific research. These describe the effect that one entity has on another entity, such as the:

• expression and activity regulators, or
• binding of two proteins together, or
• transport or chemical modification of one molecule by another, or
• effect an enzyme has on a chemical reaction, or
• association of gene expression regulation with disease, or
• regulation of a cellular process by a protein. 

Each of these “relationships” are substantiated with up to 100 literature references, and using Pathway Studio software, you can click and read the individual sentences to vet the findings based on your specific context and scope of research.  When possible, MedScan recovers the directionality of the relationship (causitive) as well as the effect (inhibits / promotes) and other contextual information surrounding the relationship. Because Ariadne MedScan Technology enables a complete processing of available scientific literature and produces high accuracy results, you always have an up-to-date and comprehensive resource for your research. Ariadne provides update to the ResNet Plant Database to subscribers twice a year, however using the MedScan Technology built into the Pathway Studio software, researchers can update their database as often as daily, and can incorporate facts into ResNet Plant from their own proprietary or private literature sources.

The ResNet Plant database includes the Arabidopsis metabolic pathway collection, ported from AraCyc by Ariadne scientists to produce a set of integrated reference pathways with standards based identifiers that can be used for reference, incorporation as building-blocks into your research projects, and in analytical workflows such as pathway and enrichment analysis.  Ariadne has additionally developed a set of plant signaling pathways which provide further building blocks for researchers.

The ResNet Plant incorporates ontology from the Plant Ontology Consortium for anatomy, growth, and development, as well as gene ontology from the Gene Ontology Consortium and from Ariadne Ontology. Ariadne Ontology is designed and maintained by Ariadne scientists to classify the function of proteins into a limited number of well defined categories and produce superior analytical results. Subscribers can import their own ontology using the Pathway Studio® software.

To extend the utility of this knowledgebase, Ariadne has fortified ResNet Plant with gene and protein definitions from rice, barley, wheat, tobacco, sorghum, soybean, tomato, and potato.  Where the gene / protein aliases are unique for these species, Ariadne also extract and incorporates these species unique relationship into ResNet Plant database.

"I think it is very good, probably the best in the market at this point since it can be frequently updated"

Magnolia Ariza-Nieto Ph.D.,
US Plant, Soil and Nutrition Lab, CORNELL University.

To learn more, please select product collateral to download and review. Registration may be required.

Please Register to request an evaluation of ResNet Plant.

To purchase the ResNet Plant database with Pathway Studio software, for more information, or to schedule a web demonstration, contact our sales department at (240) 453-6272, or (866) 340-5040 (toll free).

You can also fill-in the Contact Us form, and our sales representative will contact you.