ResNet Mammalian is the premier database of molecular interactions and includes curated signaling, cellular process and metabolic pathways, ontologies and annotations, as well as molecular interactions and functional relationships extracted from the entire contents of PubMed as well as accessible open-source full-text articles.

The database can be used with Pathway Studio® software for de novo pathway building and for experimental data analysis.  It contains functional relationships for human, rat, and mouse, linked to all of their original literature sources.

ResNet is located at your own computer or server and can be modified and managed by you.  You can use Ariadne's MedScan® technology, built into Pathway Studio to process publications or internal text sources and extract information to add to the database.

• ResNet Mammalian Database contains entity definitions for genes, proteins, microRNA, protein complexes, functional classes of enzymes, disease, cellular treatments, and cellular processes for human, mouse, and rat species.  Each definition includes a unique standards based identifier, which ensures that the contents of the database is seamlessly integrated.  Links are provided to reference sources such as Entrez Gene, SwissProt ID, Genbank, Homologene, MGI, RGD, Hugo, Unigene, ChEBI, Ensembl, PubChem, MeSH, OMIM, and so forth.  Definitions additionally include aliases, or other names for the entities to enable efficient searching and referencing during data import.
  
• Hundreds of thousands of high-quality observations of protein interactions (relationships) recovered from peer-reviewed scientific literature.  These interactions include: expression, regulation, binding, promoter binding, molecular synthesis, and molecular transport among others and include direction of effect and action where available.  Each relation includes up to 100 live references to the article as well as the sentence supporting the finding to assist the research in validating the applicability and context of the relationship in their research.
  
• A vast collection of expertly curated pathways that provide a comprehensive coverage of human metabolism, cell signaling (cell process regulation and receptor signaling), and cellular process pathways.  These pathways can be used for reference purposes, as building blocks to assemble a mechanism specific to your research, or in analytical workflow using various enrichment algorithms build into the Pathway Studio software.
  
• Support for ontologies which you may import, and preloaded with Gene Ontology Consortium "GO" as well as Ariadne Ontology (AO.)  AO is designed by Ariadne scientists and classifies proteins into a discrete set of non-overlapping cellular functions.  AO is provided to produce superiour analytical results from algorithms such as the Gene Set Enrichment Analysis algorithm (GSEA) built into Pathway Studio.

ResNet Mammalian database includes Ariadne’s proprietary protein ontology: almost 9000 genes are organized in 506 groups, and 287 signaling, cellular process, and metabolic pathways are organized in folders. It also includes an “Atlas of Signaling” pathway which represents a global overview of cell signaling on a single pathway diagram.

You can modify and expand pathways using data from the ResNet database, or by adding information from recently published or internal texts using MedScan tool.

Request a quote
Register for an evaluation