Protein : AXIN1
Owner Public
URN urn:agi-llid:8312
Hugo ID 903
Connectivity 278
Name AXIN1
Description axin 1
Notes This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
RGD ID 620859
MGI ID 1096327
Pathway Wnt signaling
AMHR-AcvR1
AcvR2B-BMPR1B
AcvR2B-ALK7
TGFR2-TGFR1
AcvR2B-AcvR1B
AcvR2B-AcvR1
AcvR2-AcvR1B
AcvR2-AcvR1
AMHR-BMPR1B
Frizzled -> CTNNB1 signaling pathway
Group development
Wnt receptor signaling pathway
frizzled signaling pathway
negative regulation of Wnt receptor signaling pathway
oocyte axis determination
cell cycle
negative regulation of progression through cell cycle
apoptosis
protein catabolism
sensory perception of sound
synapse
intracellular
cytoplasm
cytoplasmic membrane-bound vesicle
nucleus
lateral plasma membrane
signal transducer activity
protein binding
beta-catenin binding
GenBank ID NC_000016
NM_181050
NP_851393
NM_003502
NP_003493
NT_037887
NW_926018
AC_000059
AC004652
AC005202
AE006463
AAK61224
Z69667
CAI95589
CAI95590
Z99754
CAI95600
CAI95601
AB208876
BAD92113
AF009674
AAC51624
BC017447
AAH17447
BC035872
BC044648
AAH44648
CR599188
O15169
Q4TT26
Q4TT27
Q59H83
Q86YA7
NC_000083
NM_009733
NP_033863
NT_039649
NW_000124
XM_989427
XP_994521
NW_001030605
XM_914907
XP_920000
AC_000039
AC126438
AC140047
AF009011
AAC53285
BB004060
BC011544
BC055491
AAH55491
BC069954
AAH69954
BC113171
AAI13172
BG072066
BG084817
O35625
Q7TMI9
NC_005109
NM_024405
NP_077381
NW_001084656
NW_047334
AC_000078
AF017756
AAC40066
O70239
Source Curated
LocusLink ID 8312
12005
79257
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 603816
607864
114550
Alias AXIN
MGC52315
LA16c-314G4.3
axin 1
axis inhibitor 1
fused, mouse, homolog of
axis inhibition protein 1
Fu
Kb
Ki
fused
kinky
knobbly
AI316800
MGC132911
axis inhibition
GSK-3beta interacting protein rAxin
GO ID 0005515
0004871
0006915
0007049
0007275
0007222
0045786
0007309
0005737
0005622
0016328
0005634
0016055
0030178
0030163
0007605
0016023
0008013
0045202
Swiss-Prot Accession O15169
Q4TT26
Q4TT27
Q59H83
Q86YA7
O35625
Q7TMI9
O70239
Unigene ID Hs.592082
Mm.23684
Rn.31781