Regulation :

Effect positive
Mechanism phosphorylation
Owner Public
URN urn:agi-Regulation:inout-urn:agi-cas:7440-70-2:out-urn:agi-complex:3000017::positive:phosphorylation
Entities Ca2+ --+> CaM- kinase II
References 55
Connectivity 2
MedLine Reference 10485846:1111
Sentence Ca2+/CaM-dependent autophosphorylation of the CaM kinase II produces an active species that can phosphorylate substrates in the absence of Ca2+/CaM.
Journal Genes & Dev
Journal Reference v13 i17 p2231 (1999)
Journal Link http://www.genesdev.org/cgi/content/full/13/17/2231
Organism mouse
Source Curated
MedLine Reference 9252412:1022
Sentence CaM that contains bound Ca 2+ (Ca 2+ /CaM) can activate CaM kinase II and calcineurin ( 9 ), and both enzymes may play important regulatory roles ( 15-18 ).
Tissue nerve
Journal J. Biol. Chem
Journal Reference v272 i33 p20857 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/33/20857
Source Curated
MedLine Reference 9165023:1060
Sentence In the described experiments, 32Pi incorporation into autocamtide-2 in the absence of Ca2+/calmodulin (autonomous CaM kinase II activity) is expressed as percentage of incorporation in the presence of these cofactors (Ca2+-dependent CaM kinase II activity).
Tissue islet
Journal Endocrinology
Journal Reference v138 i6 p2359 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/138/6/2359
Organism rat
Source Curated
MedLine Reference 12660151:1150
Sentence Indeed, KN-93 treatment reduced Ca2+-dependent CaMK-II activity by 33% at G0 (1.00 ???± 0.04 vs. 0.67 ???± 0.11; P < 0.05) and 52% at G1/S (1.19 ???± 0.03 vs. 0.57 ???± 0.05; P < 0.01) ( Fig. 5 ) at a drug concentration and time of exposure identical to those used to inhibit repression of PMCA4 expression ( Fig. 6 ).
Tissue smooth muscle
Journal Cell Phys
Journal Reference v285 i1 pC88 (2003)
Journal Link http://ajpcell.physiology.org/cgi/content/full/285/1/C88
Organism mouse
Source Curated
CellLineName VSMC
MedLine Reference 9688835:1129
Sentence In vitro phosphorylations were also performed with recombinant Ca2+/calmodulin-dependent protein (CAM kinase) II and recombinant protein kinase (PKC)-alpha in the same reaction mixture as for recombinant PKA except that 0.2 ???µM calmodulin and 1.5 mM CaCl2 were included in CAM kinase II assays and 10 ???µg phosphatidylserine, 2 ???µg 1,2-dioleoyl- sn -glycerol, and 0.1 mM CaCl2 were included in PKC-alpha assays.
Journal Cell Phys
Journal Reference v275 i1 pC56 (1998)
Journal Link http://ajpcell.physiology.org/cgi/content/full/275/1/C56
Source Curated
Source Curated
CellType astrocyte
Source Curated
CellType neural
Source Curated
CellType neural
CellLineName DRG
MedLine Reference 11435029:2
Tissue cortex
Organ brain
Organism rat
Source Curated
MedLine Reference 10704484:1142
Journal J. Neurosci
Journal Reference v20 i6 p2104 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/6/2104
Organism drosophila
Source Curated
MedLine Reference 12023367:1032
Journal J. Immunol
Journal Reference v168 i11 p5682 (2002)
Journal Link http://www.jimmunol.org/cgi/content/full/168/11/5682
Organism rat
Source Curated
MedLine Reference 10330414:1232
Journal J. Cell Biol
Journal Reference v145 i4 p889 (1999)
Journal Link http://www.jcb.org/cgi/content/full/145/4/889
Source Curated
MedLine Reference 9920909:1220
Journal J. Biol. Chem
Journal Reference v274 i6 p3610 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/6/3610
Source Curated
CellType neural
MedLine Reference 10809760:1161
Journal J. Biol. Chem
Journal Reference v275 i20 p15239 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/20/15239
Organ heart
Organism rat
Source Curated
MedLine Reference 10799536:1193
Journal J. Biol. Chem
Journal Reference v275 i19 p14524 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/19/14524
Organism mouse
Source Curated
CellType t cell
CellLineName WEHI7.2
MedLine Reference 10531355:1214
Journal J. Biol. Chem
Journal Reference v274 i44 p31524 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/44/31524
Organ brain
Organism drosophila
Source Curated
MedLine Reference 9412499:7
Tissue dorsal root ganglion
Source Curated
CellType neural
MedLine Reference 11891759:1
Organ brain
Source Curated
MedLine Reference 15715657:6
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 15242787:1
Tissue egg
Organism mouse
Source Curated
MedLine Reference 12654339:2
Organ hippocampal
Organism rat
Source Curated
CellLineName CA1
MedLine Reference 10700251:1
Organism rat
Source Curated
MedLine Reference 11324526:2
Tissue cortex
Organ hippocampal
Organism rat
Source Curated
MedLine Reference 11559707:1040
Journal J. Biol. Chem
Journal Reference v276 i47 p43734 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/47/43734
Source Curated
CellType t cell
MedLine Reference 11274168:1019
Journal J. Biol. Chem
Journal Reference v276 i23 p20005 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/23/20005
Source Curated
MedLine Reference 10642313:1116
Journal Hypertension
Journal Reference v35 i1 p292 (2000)
Journal Link http://hyper.ahajournals.org/cgi/content/full/35/1/292
Organ heart
Organism rat
Source Curated
MedLine Reference 9048624:1198
Tissue thyroid
Journal Endocrinology
Journal Reference v138 i3 p1170 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/138/3/1170
Organism bovine
Source Curated
MedLine Reference 12746302:1151
Journal Endocrinology
Journal Reference v144 i6 p2409 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/144/6/2409
Organism mouse
Source Curated
CellLineName LbetaT2
Journal Cell
Journal Reference v93 i4 p495 (1998)
Journal Link http://www.cell.com/cgi/content/full/93/4/495
Source Curated
CellType neural
MedLine Reference 12372801:1409
Tissue smooth muscle
Journal Cell Phys
Journal Reference v283 i5 pC1399 (2002)
Journal Link http://ajpcell.physiology.org/cgi/content/full/283/5/C1399
Organism mouse
Source Curated
MedLine Reference 11078683:1112
Journal Cell Phys
Journal Reference v279 i6 pC1694 (2000)
Journal Link http://ajpcell.physiology.org/cgi/content/full/279/6/C1694
Organism bovine
Source Curated
CellLineName AG
MedLine Reference 12388397:1202
Journal Renal Phys
Journal Reference v284 i2 pF293 (2003)
Journal Link http://ajprenal.physiology.org/cgi/content/full/284/2/F293
Organ kidney
Source Curated
CellLineName HEK 293
MedLine Reference 10553576:4
Tissue islet
Source Curated
CellType Insulin-producing cell
MedLine Reference 7500040:9
Source Curated
CellType b cell
MedLine Reference 10331647:5
Organism rat
Source Curated
CellType Insulin-producing cell
MedLine Reference 8519682:0
Organism mouse
Source Curated
MedLine Reference 1660442:2
Organ brain
Organism rat
Source Curated
MedLine Reference 9422694:1121
Tissue retina
Journal Science
Journal Reference v279 i5348 p222 (1998)
Journal Link http://www.sciencemag.org/cgi/content/full/279/5348/222
Organism frog
Source Curated
CellType neural
MedLine Reference 11408603:1321
Journal Mol. Pharm
Journal Reference v60 i1 p80 (2001)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/60/1/80
Source Curated
CellType neural
MedLine Reference 9435202:1255
Journal JPET
Journal Reference v284 i1 p388 (1998)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/284/1/388
Organism rat
Source Curated
MedLine Reference 10662824:1206
Tissue nerve
Journal J. Neurosci
Journal Reference v20 i4 p1342 (2000)
Journal Link http://www.jneurosci.org/cgi/content/full/20/4/1342
Organism rat
Source Curated
Journal J. Neurochem
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2002.00760.x/full/
Organ hippocampal
Source Curated
CellLineName CA1
MedLine Reference 10811820:1183
Journal J. Cell Biol
Journal Reference v149 i4 p783 (2000)
Journal Link http://www.jcb.org/cgi/content/full/149/4/783
Organ brain
Organism frog
Source Curated
MedLine Reference 9651352:1023
Journal J. Biol. Chem
Journal Reference v273 i28 p17579 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/28/17579
Source Curated
MedLine Reference 9341200:1032
Journal J. Biol. Chem
Journal Reference v272 i43 p27464 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/43/27464
Organism rat
Source Curated
MedLine Reference 9312133:1025
Journal J. Biol. Chem
Journal Reference v272 i40 p25195 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/40/25195
Organism rat
Source Curated
CellType astrocyte
MedLine Reference 9305859:1126
Journal J. Biol. Chem
Journal Reference v272 i39 p24133 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/39/24133
Organ hippocampal
Organism rat
Source Curated
CellType neural
MedLine Reference 8939965:1218
Journal J. Biol. Chem
Journal Reference v271 i47 p30149 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/47/30149
Source Curated
MedLine Reference 1335039:8
Source Curated
MedLine Reference 11931644:0
Source Curated
MedLine Reference 9409621:1
Source Curated
MedLine Reference 1334558:0
Source Curated
Source Curated
CellLineName PC 12
Source Curated
CellLineName PC 12
MedLine Reference 8969222:1101
Journal J. Biol. Chem
Journal Reference v271 i52 p33561 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/52/33561
Organ heart
Organism rat
Source Curated