Binding :


Connectivity	2
Owner	Public
URN	urn:agi-Binding:inout-urn:agi-llid:8312:inout-urn:agi-llid:2932:
Entities	AXIN1 ---- GSK3B
References	129


MedLine Reference	9734785:2
Sentence	We found that Axin interacts with beta-catenin and glycogen synthase kinase-3beta (GSK-3beta).


MedLine Reference	10882137:3
Sentence	Through another domain, dishevelled recruits GBP/Frat1 to the APC-axin-GSK3 complex.
Tissue	egg


MedLine Reference	10318824:1
Sentence	From the binding experiments, we defined the domains of Axin that bind glycogen synthase kinase-3beta (GSK-3beta) and beta-catenin.
Organism	Mus musculus


MedLine Reference	10196136:0


MedLine Reference	10072781:1


MedLine Reference	15817486:1
Organism	Mus musculus


MedLine Reference	16303557:1


MedLine Reference	9601644:5
Tissue	egg


MedLine Reference	10428961:6


MedLine Reference	10684251:2
Tissue	egg
Organism	Rattus norvegicus


MedLine Reference	14734535:1
Organism	Mus musculus


MedLine Reference	11390362:2
Tissue	egg


MedLine Reference	11278246:3
Organism	Mus musculus


MedLine Reference	12711303:4


MedLine Reference	16815997:4
Tissue	egg
Organism	Mus musculus


MedLine Reference	9601641:6


MedLine Reference	9501208:1092
Journal	PNAS
Journal Reference	v95 i6 p3020 (1998)
Journal Link	http://www.pnas.org/cgi/content/full/95/6/3020
CellLineName	293


MedLine Reference	10228155:1118
Journal	EMBO
Journal Reference	v18 i9 p2401 (1999)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/18/9/2401
Organism	Mus musculus
CellLineName	293T


MedLine Reference	10490650:1274
Journal	Mol. Cell. Biol
Journal Reference	v19 i10 p7147 (1999)
Journal Link	http://mcb.asm.org/cgi/content/full/19/10/7147
Organism	Mus musculus
CellLineName	SW 480


MedLine Reference	11967263:10186
Journal	J. Biol. Chem
Journal Reference	v277 i26 p23330
Journal Link	http://www.jbc.org/cgi/content/full/277/26/23330


MedLine Reference	10419494:10206
Journal	J. Biol. Chem
Journal Reference	v274 i31 p21790
Journal Link	http://www.jbc.org/cgi/content/full/274/31/21790


MedLine Reference	11524435:10070
Journal	J. Cell Biol
Journal Reference	v154 i5 p983
Journal Link	http://www.jcb.org/cgi/content/full/154/5/983


MedLine Reference	11486025:1200
Journal	Mol. Cell. Biol
Journal Reference	v21 i17 p5857 (2001)
Journal Link	http://mcb.asm.org/cgi/content/full/21/17/5857
Organism	Mus musculus


MedLine Reference	11408485:1146
Journal	J. Biol. Chem
Journal Reference	v276 i34 p32152 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/34/32152


MedLine Reference	15893313:4
CellLineName	HEK 293


MedLine Reference	9556553:5


MedLine Reference	15670774:2
CellLineName	HEK 293


MedLine Reference	16443747:2


MedLine Reference	10023673:5
CellType	Brain Stem
Organism	Mus musculus


MedLine Reference	12421363:8


MedLine Reference	16199882:4
Organism	Mus musculus


MedLine Reference	11707456:7


MedLine Reference	15799972:10287
Journal	J. Biol. Chem
Journal Reference	v280 i23 p22044
Journal Link	http://www.jbc.org/cgi/content/full/280/23/22044
Organism	Rattus norvegicus


MedLine Reference	16567647:10028
Journal	PNAS
Journal Reference	v103 i14 p5397
Journal Link	http://www.pnas.org/cgi/content/full/103/14/5397


MedLine Reference	12796505:10040
Journal	J. Biol. Chem
Journal Reference	v278 i35 p33067
Journal Link	http://www.jbc.org/cgi/content/full/278/35/33067
Organism	Mus musculus


MedLine Reference	16428445:10024
Journal	Mol. Cell. Biol
Journal Reference	v26 i3 p898
Journal Link	http://mcb.asm.org/cgi/content/full/26/3/898


MedLine Reference	15537647:10037
Journal	J. Biol. Chem
Journal Reference	v280 i3 p2388
Journal Link	http://www.jbc.org/cgi/content/full/280/3/2388
Organism	Mus musculus


MedLine Reference	15282335:10309
Journal	Mol. Biol. Cell
Journal Reference	v15 i10 p4544
Journal Link	http://www.molbiolcell.org/cgi/content/full/15/10/4544
Organism	Mus musculus


MedLine Reference	12799363:10055
Journal	J. Biol. Chem
Journal Reference	v278 i34 p31781
Journal Link	http://www.jbc.org/cgi/content/full/278/34/31781


MedLine Reference	12584189:10119
Journal	J. Biol. Chem
Journal Reference	v278 i16 p13995
Journal Link	http://www.jbc.org/cgi/content/full/278/16/13995
Organism	Mus musculus


MedLine Reference	11997515:1387
Journal	Mol. Cell. Biol
Journal Reference	v22 i11 p3803 (2002)
Journal Link	http://mcb.asm.org/cgi/content/full/22/11/3803
Organism	Rattus norvegicus


MedLine Reference	10330403:1393
Journal	J. Cell Biol
Journal Reference	v145 i4 p741 (1999)
Journal Link	http://www.jcb.org/cgi/content/full/145/4/741


MedLine Reference	11861647:10180
Journal	J. Biol. Chem
Journal Reference	v277 i18 p16147
Journal Link	http://www.jbc.org/cgi/content/full/277/18/16147
Organism	Mus musculus


MedLine Reference	10521419:1032
Journal	J. Biol. Chem
Journal Reference	v274 i43 p30419 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/43/30419
Organism	Mus musculus


MedLine Reference	9891076:10035


MedLine Reference	14600025:10141
Journal	Genes & Dev
Journal Reference	v17 i22 p2753
Journal Link	http://www.genesdev.org/cgi/content/full/17/22/2753


MedLine Reference	10688669:10248
Journal	Mol. Cell. Biol
Journal Reference	v20 i6 p2228
Journal Link	http://mcb.asm.org/cgi/content/full/20/6/2228


MedLine Reference	12556519:10024
Journal	J. Biol. Chem
Journal Reference	v278 i16 p14066
Journal Link	http://www.jbc.org/cgi/content/full/278/16/14066


MedLine Reference	11154277:10339
Journal	Mol. Cell. Biol
Journal Reference	v21 i3 p902
Journal Link	http://mcb.asm.org/cgi/content/full/21/3/902
Organism	Mus musculus


MedLine Reference	9482734:1148
Journal	EMBO
Journal Reference	v17 i5 p1371 (1998)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/17/5/1371
Organism	Mus musculus
CellLineName	COS


MedLine Reference	11425858:1227
Tissue	egg
Journal	J. Biol. Chem
Journal Reference	v276 i35 p33147 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/35/33147
Organism	Rattus norvegicus


MedLine Reference	12147701:1133
Journal	J. Biol. Chem
Journal Reference	v277 i40 p36955 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/40/36955
CellLineName	COS


MedLine Reference	11589691:10223
Journal	Eur. J. Biochem
Journal Reference	v268 i19 p5001
Journal Link	http://www.ejbiochem.org/cgi/content/full/268/19/5001


MedLine Reference	15878878:10289
Journal	J. Biol. Chem
Journal Reference	v280 i26 p25087
Journal Link	http://www.jbc.org/cgi/content/full/280/26/25087
Organism	Mus musculus


MedLine Reference	10488109:1175
Journal	J. Biol. Chem
Journal Reference	v274 i39 p27682 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/39/27682


MedLine Reference	11585731:1120
Journal	Cancer Res
Journal Reference	v61 i19 p7039 (2001)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/61/19/7039


MedLine Reference	12000790:10176
Journal	Genes & Dev
Journal Reference	v16 i9 p1066
Journal Link	http://www.genesdev.org/cgi/content/full/16/9/1066


MedLine Reference	12192039:10154
Journal	Mol. Cell. Biol
Journal Reference	v22 i18 p6393
Journal Link	http://mcb.asm.org/cgi/content/full/22/18/6393


MedLine Reference	10698942:10269
Journal	EMBO
Journal Reference	v19 i5 p1010
Journal Link	http://emboj.oupjournals.org/cgi/content/full/19/5/1010


MedLine Reference	15699046:10222
Journal	J. Biol. Chem
Journal Reference	v280 i14 p13616
Journal Link	http://www.jbc.org/cgi/content/full/280/14/13616
Organism	Mus musculus


MedLine Reference	12615961:10190
Journal	Cell Sci
Journal Reference	v116 i7 p1175
Journal Link	http://jcs.biologists.org/cgi/content/full/116/7/1175


MedLine Reference	12874278:10021
Journal	J. Biol. Chem
Journal Reference	v278 i40 p38758
Journal Link	http://www.jbc.org/cgi/content/full/278/40/38758
Organism	Mus musculus


MedLine Reference	9920888:10182


MedLine Reference	11487578:1109
Journal	J. Biol. Chem
Journal Reference	v276 i42 p39037 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/42/39037
CellLineName	SW 480


Organism	Mus musculus


Journal	J. Biol. Chem
Journal Reference	v276 i34 p32152 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/34/32152
CellLineName	HepG 2


Journal	Cell
Journal Reference	v103 i2 p311.2 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/311.2


Journal	Cell
Journal Reference	v103 i2 p311 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/311


Tissue	egg


Tissue	egg


Tissue	egg


Tissue	egg


MedLine Reference	10906131:1103
Journal	J. Biol. Chem
Journal Reference	v275 i44 p34399 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/44/34399
CellLineName	COS


MedLine Reference	10339594:1109
Journal	PNAS
Journal Reference	v96 i11 p6371 (1999)
Journal Link	http://www.pnas.org/cgi/content/full/96/11/6371
CellLineName	293T


MedLine Reference	12727872:1021
Journal	EMBO
Journal Reference	v22 i9 p2047 (2003)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/22/9/2047


MedLine Reference	15466414:10264
Journal	J. Biol. Chem
Journal Reference	v279 i49 p51075
Journal Link	http://www.jbc.org/cgi/content/full/279/49/51075
Organism	Mus musculus


MedLine Reference	15632169:10291
Journal	J. Biol. Chem
Journal Reference	v280 i10 p9509
Journal Link	http://www.jbc.org/cgi/content/full/280/10/9509
Organism	Mus musculus


MedLine Reference	15358764:10032
Journal	J. Biol. Chem
Journal Reference	v279 i49 p51581
Journal Link	http://www.jbc.org/cgi/content/full/279/49/51581


MedLine Reference	11533051:10280
Journal	J. Biol. Chem
Journal Reference	v276 i44 p40910
Journal Link	http://www.jbc.org/cgi/content/full/276/44/40910
Organism	Rattus norvegicus


MedLine Reference	15367660:1017
Tissue	egg
Journal	Mol. Cell. Biol
Journal Reference	v24 i19 p8386 (2004)
Journal Link	http://mcb.asm.org/cgi/content/full/24/19/8386
Organism	Mus musculus


CellLineName	HEK 293


CellLineName	HEK 293


CellLineName	HEK 293


Organism	Mus musculus


Organism	Mus musculus


Organism	Mus musculus


Organism	Mus musculus


Journal	J. Neurochem
Journal Link	http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2001.00453.x/full/


Journal	J. Neurochem
Journal Reference	v83 i4 01197 (2002)
Journal Link	http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2002.01197.x/full/


Journal	J. Neurochem
Journal Reference	v83 i4 01197 (2002)
Journal Link	http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2002.01197.x/full/


Journal	J. Neurochem
Journal Reference	v83 i4 01197 (2002)
Journal Link	http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2002.01197.x/full/
CellLineName	PC 12


Journal	J. Neurochem
Journal Reference	v90 i2 02497 (2004)
Journal Link	http://www.blackwell-synergy.com/links/doi/10.1046/j.0022-3042.2004.02497.x/full/


Tissue	egg


Tissue	egg
Organism	Rattus norvegicus


CellType	neural
Journal	J. Cell Biol
Journal Reference	v164 i2 p243 (2004)
Journal Link	http://www.jcb.org/cgi/content/full/164/2/243


CellType	Brain Stem
Organism	Mus musculus


Organism	Mus musculus


Organism	Mus musculus


Tissue	egg
Organism	Rattus norvegicus


MedLine Reference	131103349:11104


MedLine Reference	131101553:11199


MedLine Reference	3305078818
Journal	Cell
Journal Reference	v103 i2 p311.1 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/311.1


MedLine Reference	131102307:11090


MedLine Reference	11707456:2
Sentence	This report shows that GSK-3 forms a low affinity homodimer that is disrupted by binding to Axin and Frat.
Source	Curated


MedLine Reference	11390362:1013
Sentence	The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription.
Tissue	egg
Journal	Genes & Dev
Journal Reference	v15 i11 p1427 (2001)
Journal Link	http://www.genesdev.org/cgi/content/full/15/11/1427
Source	Curated


MedLine Reference	10228155:1020
Sentence	GSK-3eta, in concert with Axin, which associates with GSK-3eta (Ikeda et al ., 1998 ), appears to phosphorylate eta-catenin at these sites.
Organ	colon
Journal	EMBO
Journal Reference	v18 i9 p2401 (1999)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/18/9/2401
Organism	Mus musculus
Source	Curated


MedLine Reference	12000790:1176
Sentence	Then, any signal (including a Wnt signal) that would affect the affinity of association between axin and GSK3 might influence the progression of the eta-catenin phosphorylation cascade.
Journal	Genes & Dev
Journal Reference	v16 i9 p1066 (2002)
Journal Link	http://www.genesdev.org/cgi/content/full/16/9/1066
Source	Curated


MedLine Reference	11589691:1224
Sentence	Instead, it appears to involve disruption of the interaction of Axin with GSK3, and hence also the release of eta-catenin from the complex by proteins called dishevelled and FRAT (frequently rearranged in advanced T-cell lymphomas).
Journal	Eur. J. Biochem
Journal Reference	v268 i19 p5001 (2001)
Journal Link	http://www.ejbiochem.org/cgi/content/full/268/19/5001
Source	Curated


MedLine Reference	12615961:1192
Sentence	Comparison of mutations that affect binding of GSK-3 to axin and GBP, as well as analysis of the crystal structure of a GSK-3-FRAT-tide complex, indicates that the binding sites on GSK-3 for GBP/FRAT and axin overlap (Bax et al., 2001 ; Ferkey and Kimelman, 2002 ; Fraser et al., 2002 ).
Journal	Cell Sci
Journal Reference	v116 i7 p1175 (1997)
Journal Link	http://jcs.biologists.org/cgi/content/full/116/7/1175
Source	Curated


MedLine Reference	10419494:1206
Journal	J. Biol. Chem
Journal Reference	v274 i31 p21790 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/31/21790
Source	Curated


MedLine Reference	10318824:1009
Tissue	cardiovascular
Journal	J. Biol. Chem
Journal Reference	v274 i20 p14090 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/20/14090
Organism	Mus musculus
Source	Curated


MedLine Reference	10196136:1029
Journal	J. Biol. Chem
Journal Reference	v274 i16 p10681 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/16/10681
Source	Curated
CellLineName	COS


Journal	Cell
Journal Reference	v103 i2 p311 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/311
Source	Curated


Journal	Cell
Journal Reference	v103 i2 p311.2 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/311.2
Source	Curated


MedLine Reference	11524435:1070
Journal	J. Cell Biol
Journal Reference	v154 i5 p983 (2001)
Journal Link	http://www.jcb.org/cgi/content/full/154/5/983
Source	Curated


MedLine Reference	10684251:1062
Journal	J. Cell Biol
Journal Reference	v148 i4 p691 (2000)
Journal Link	http://www.jcb.org/cgi/content/full/148/4/691
Organism	Rattus norvegicus
Source	Curated


MedLine Reference	9556553:1011
Journal	J. Biol. Chem
Journal Reference	v273 i18 p10823 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/18/10823
Source	Curated


MedLine Reference	12796505:1040
CellType	oocyte
Journal	J. Biol. Chem
Journal Reference	v278 i35 p33067 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/35/33067
Organism	Mus musculus
Source	Curated


MedLine Reference	12584189:1103
Journal	J. Biol. Chem
Journal Reference	v278 i16 p13995 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/16/13995
Organism	Mus musculus
Source	Curated
CellLineName	HEK 293


MedLine Reference	12556519:1024
Journal	J. Biol. Chem
Journal Reference	v278 i16 p14066 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/16/14066
Source	Curated


MedLine Reference	11967263:1043
Journal	J. Biol. Chem
Journal Reference	v277 i26 p23330 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/26/23330
Source	Curated


MedLine Reference	11861647:1031
Journal	J. Biol. Chem
Journal Reference	v277 i18 p16147 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/18/16147
Organism	Mus musculus
Source	Curated


MedLine Reference	11533051:1281
Tissue	fat
Journal	J. Biol. Chem
Journal Reference	v276 i44 p40910 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/44/40910
Organism	Rattus norvegicus
Source	Curated


MedLine Reference	11408485:1136
Journal	J. Biol. Chem
Journal Reference	v276 i34 p32152 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/34/32152
Source	Curated


MedLine Reference	10428961:4
Source	Curated


MedLine Reference	9501208:1075
Journal	PNAS
Journal Reference	v95 i6 p3020 (1998)
Journal Link	http://www.pnas.org/cgi/content/full/95/6/3020
Source	Curated
CellLineName	SW 480


MedLine Reference	12192039:1154
Journal	Mol. Cell. Biol
Journal Reference	v22 i18 p6393 (2002)
Journal Link	http://mcb.asm.org/cgi/content/full/22/18/6393
Source	Curated
CellLineName	COS I


MedLine Reference	10688669:1206
Journal	Mol. Cell. Biol
Journal Reference	v20 i6 p2228 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/6/2228
Source	Curated


MedLine Reference	10490650:1036
Tissue	egg
Journal	Mol. Cell. Biol
Journal Reference	v19 i10 p7147 (1999)
Journal Link	http://mcb.asm.org/cgi/content/full/19/10/7147
Organism	Mus musculus
Source	Curated
CellLineName	COS