Protein DVL1

Owner Public
URN urn:agi-llid:1855
Notes Amplification and increased expression of the DVL-1 gene is associated with breast carcinogenesis Amplification and increased expression of the DVL-1 gene is associated with breast carcinogenesis. CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin. Ccd1 drastically inhibited JNK activation both by Axin and by Dvl. DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene. The DVL1 gene spans a region of approximately 13.8 kb with 15 exons and six rare sequence variations. None of these had any association with late onset AD. Amplification and increased expression of the DVL-1 gene may play some role in the development of a portion of human cervical squamous cell cancer through derangement of the Wnt signaling pathway. Interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates.
Connectivity 8
Name DVL1
Description dishevelled, dsh homolog 1 (Drosophila)

Cell Localization Cytoplasm

Mouse chromosome position 4 82.0 cM

OMIM ID 601365

GO ID 0003674
0005515
0004871
0016055
0009653
0007507
0007242
0007275
0005737
0005622
0048813
0007528
0007269
0043113
0001505
0050808
0016023
0015630
0045202
0019717
0048365
0019901
0030424
0043025
0030425
0030426
0005874
0005554
0007222

Pathway WNT signaling via MAPK cascade
WNT -> beta-catenin signaling
Notch -> HES/HEY signaling

Hugo ID 3084

Rat chromosome position 5q36

Human chromosome position 1p36

Swiss-Prot Accession P54792
Q8NA39
P51141
Q86TH3
Q571M1
Q9WVB9
O14640
Q5TA33
Q59G99
Q5TA34
Q6PJD6
Q5TA35

GenBank ID NC_000001
NM_182779
NP_877580
NM_004421
NP_004412
NT_004350
NW_927662
AL139287
CAI23185
CAI23187
CH471183
EAW56224
EAW56225
EAW56226
EAW56227
AB209210
BAD92447
AF006011
AAB65242
AK093189
BAC04089
AK095867
BC017225
AAH17225
BC025292
BC050454
AAH50454
BC111419
BP305846
CR616573
U46461
AAC50682
O14640
P54792
Q59G99
Q5TA34
Q6PJD6
Q86TH3
Q8NA39
NC_000070
NM_010091
NP_034221
NT_039268
NW_001030773
AC_000026
AL670236
CAM18392
CH466594
EDL15043
EDL15044
EDL15045
U28138
AAA74049
AK155349
BAE33208
AK162430
BAE36912
AK220168
BAD90353
BC018593
BC051991
BC088987
BU702464
BY727676
U10115
AAA82175
P51141
Q3TRW4
Q3U2D3
Q571M1
NC_005104
NM_031820
NP_114008
NW_047732
NW_001084844
AC_000073
AF143547
AAD41492
AF143548
AF143549
AAD41493
AF143550
CH473968
EDL81336
AF143545
AAD33896
AF143546
AAD33897
BC062070
BC090034
BC160920
AAI60920
Q9WVB9
NW_921350
Q5TA33
Q5TA35
BB324672
AC_000044
NP_864764
NM_181870
CAI23186

LocusLink ID 1855
13542
83721
348497

Unigene ID Hs.709300
Mm.3400
Rn.144610
Hs.74375

KEGG ID hsa:1855
mmu:13542
rno:83721

Alias DVL
MGC54245
dishevelled 1
dishevelled 1 (homologous to Drosophila dsh)
KIAA4029
mKIAA4029
RP23-242K15.15
dishevelled, dsh homolog 1
dvl-1
dishevelled-1
dishevelled, dsh homolog 1 (Drosophila)
DSH homolog 1
Dvl1
Segment polarity protein dishevelled homolog DVL-1
homologous to dsh
dishevelled I
dishevelled, dsh homolog I
DSH homolog I
Segment polarity protein dishevelled homolog DVL I
Dvl I
dishevelled, dsh homolog
dishevelled, dsh homolog (Drosophila)

Homologene ID 20926

Organism Homo sapiens
Mus musculus
Rattus norvegicus

MGI ID 94941

RGD ID 620632