Protein : TLR7
Owner Public
URN urn:agi-llid:51284
Hugo ID 15631
Connectivity 123
Name TLR7
Description toll-like receptor 7 (predicted)
Notes The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
RGD ID 1563357
MGI ID 2176882
Cell Localization Plasma membrane
Pathway Toll-Like Receptor pathway
TLR2/4/5/7/9 -> AP-1 signaling pathway
TLR4/5/7/9 -> NF-kB signaling pathway
Group Receptors
positive regulation of interferon-alpha biosynthesis
positive regulation of interferon-beta biosynthesis
positive regulation of interferon-gamma biosynthesis
positive regulation of interleukin-8 biosynthesis
inflammatory response
immune response
defense response to virus
membrane
integral to membrane
extracellular space
double-stranded RNA binding
single-stranded RNA binding
siRNA binding
receptor activity
transmembrane receptor activity
GenBank ID NC_000023
NM_016562
NP_057646
NT_011757
NW_927700
AC_000066
AC005859
AF240467
AAF60188
AF245702
AAF78035
AY358292
AAQ88659
BC033651
AAH33651
Q9NYK1
NC_000086
NM_133211
NP_573474
NT_039718
NW_001035190
XM_989349
XP_994443
NW_042641
AC_000042
AL731735
AF334942
AAL73191
AF334943
AAL73192
AK036549
BAC29472
AK154906
BAE32916
AK156908
BAE33892
AK172680
BAE43127
AY035889
AAK62676
BC120596
AAI20597
P58681
Q548J0
NC_005120
XM_228909
XP_228909
NW_001091916
XM_001066039
XP_001066039
NW_048039
AC_000089
Source Curated
LocusLink ID 51284
170743
317468
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 300365
Alias toll-like receptor 7
RGD1563357
toll-like receptor 7 (predicted)
GO ID 0003725
0035197
0003727
0004888
0051607
0006954
0045356
0045359
0045078
0045416
0016021
0016020
0004872
0006955
0005615
Swiss-Prot Accession Q9NYK1
P58681
Q548J0
Unigene ID Hs.443036
Mm.23979