Protein : MAP2K3
Owner Public
URN urn:agi-llid:5606
Hugo ID 6843
Connectivity 351
Name MAP2K3
Description mitogen activated protein kinase kinase 3
Notes The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
RGD ID 1306620
MGI ID 1346868
Pathway p38 MAPK
Toll-Like Receptor pathway
MAPK signaling
TNFRSF6 -> DDIT3 signaling pathway
EDG3/5 -> AP-1 signaling pathway
TNFRSF6 -> RB1-E2F1 signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
VIPR1 -> CEBPB signaling pathway
EDG3/5 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
EGFR -> ATF2 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> TP53 signaling pathway
ERBB2/3 -> SP1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
EGFR/ERBB3 -> MEF2A signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB3 -> MEF2C signaling pathway
ENDRA -> AP-1 signaling pathway
ENDRA -> CREB1 signaling pathway
ENDRB -> AP-1 signaling pathway
F2R -> CREB1 signaling pathway
ENDRB -> CREB1 signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
ENDRB -> ELK4-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
PTAFR -> AP-1 signaling pathway
PTAFR -> ATF1 signaling pathway
PTAFR -> CREB1 signaling pathway
PTAFR -> ELK1-SRF signaling pathway
PTAFR -> ELK4-SRF signaling pathway
PTAFR -> NF-kB signaling pathway
IL1R -> NF-kB signaling pathway
ERBB2 -> ETV1 signaling pathway
CD28 -> ATF1 signaling pathway
CD28 -> ATF2 signaling pathway
CD28 -> CREB1 signaling pathway
TGFBR -> AP-1 signaling pathway
CD28 -> NF-kB signaling pathway
TGFBR -> ATF2 signaling pathway
TGFBR -> CREB1 signaling pathway
TGFBR -> ELK1-SRF signaling pathway
TGFBR -> ELK4-SRF signaling pathway
TGFBR -> GADD153 signaling pathway
TGFBR -> MAX signaling pathway
TGFBR -> MEF2A signaling pathway
TGFBR -> MEF2C signaling pathway
TGFBR -> TP53 signaling pathway
ITGB1 -> AP-1 signaling pathway
TLR2/4/5/7/9 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> NF-kB signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
TLR2/6 -> AP-1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CNRs -> CREB1 signaling pathway
TNFRs -> AP-1 signaling pathway
CNRs -> ELK1-SRF signaling pathway
CNRs -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
TNFRs -> ATF2 signaling pathway
TNFRs -> CREB1 signaling pathway
TNFRs -> ELK1-SRF signaling pathway
TNFRs -> ELK4-SRF signaling pathway
TNFRs -> NF-kB signaling pathway
NGFR -> AP-1 signaling pathway
ICAM1 -> AP-1 signaling pathway
TNFRs -> TP53 signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
NGFR -> CEBPB signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> CREB1 signaling pathway
NGFR -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
NGFR -> ELK4-SRF signaling pathway
NGFR -> NF-kB signaling pathway
DRD2 -> CREB1 signaling pathway
NGFR -> TP53 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
TNFRSF5 -> RB1-E2F1 signaling pathway
EDARs -> NF-kB signaling pathway
Group Kinases
signal transduction
MAPKKK cascade
activation of MAPK activity
regulation of cytokine biosynthesis
protein amino acid phosphorylation
positive regulation of transcription, DNA-dependent
inflammatory response
positive regulation of protein kinase activity
nucleotide binding
protein binding
ATP binding
transferase activity
kinase activity
protein kinase activity
protein serine-threonine kinase activity
protein-tyrosine kinase activity
MAP kinase kinase activity
GenBank ID NC_000017
NM_145109
NP_659731
NM_002756
NP_002747
NM_145110
NP_659732
NT_010718
NW_926672
XM_944206
XP_949299
AC_000060
AC087294
U66840
AAB40653
AK093838
AK223490
BAD97210
BC032478
AAH32478
BM836867
CR536514
CAG38752
CR541793
CAG46592
CR597835
D87116
BAA13248
L36719
AAC41718
U66839
AAB40652
P46734
Q53EZ9
Q6FHG1
Q6FI23
NC_000077
NM_008928
NP_032954
NT_096135
NW_000039
NW_001030465
AC_000033
AL603830
CAI25794
AI481780
AK008141
BAB25489
AK011002
BAB27321
AK053378
AK150067
BAE29279
AK159379
BAE35034
AK166255
BAE38665
AK166507
BAE38817
AK167209
BAE39336
AK167442
BAE39528
AK168710
BAE40552
AK176968
AK179609
AK181928
AK185191
AK197832
AK219340
BC007467
AAH07467
BG077180
D87115
BAA13247
X93150
CAA63649
O09110
Q5SWN9
NC_005109
XM_239239
XP_239239
NW_001084656
XM_001077724
XP_001077724
NW_047334
AC_000078
BC100095
AAI00096
Source Curated
LocusLink ID 5606
26397
303200
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 602315
Alias MEK3
MKK3
MAPKK3
PRKMK3
mitogen-activated protein kinase kinase 3
MAPK/ERK kinase 3
MAP kinase kinase 3
dual specificity mitogen activated protein kinase kinase 3
mMKK3b
AW212142
RP23-467E19.1
mitogen activated protein kinase kinase 3
protein kinase, mitogen-activated, kinase 3
GO ID 0005524
0004708
0000166
0005515
0004674
0004713
0016740
0045860
0045893
0006468
0007165
0016301
0004672
0000165
0000187
0006954
0042035
Swiss-Prot Accession P46734
Q53EZ9
Q6FHG1
Q6FI23
O09110
Q5SWN9
Unigene ID Hs.514012
Mm.18494
Rn.100064