Protein : MAP3K14


Owner	Public
URN	urn:agi-llid:9020
Hugo ID	6853
Connectivity	28
Name	MAP3K14
Description	mitogen-activated protein kinase kinase kinase 14 (predicted)
Notes	This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.


RGD ID	1310487


MGI ID	1858204


Pathway	NF kappa B
	NF-kB Signaling
	Toll-Like Receptor pathway
	IL1
	IL18
	ENDRA -> AP-1 signaling pathway
	CD28 -> NF-kB signaling pathway
	TNFRs -> AP-1 signaling pathway
	TNFRs -> NF-kB signaling pathway
	NGFR -> AP-1 signaling pathway
	TNFRSF1A -> AP-1 signaling pathway
	NGFR -> NF-kB signaling pathway
	EDARs -> NF-kB signaling pathway


Group	Kinases
	protein amino acid phosphorylation
	nucleotide binding
	protein binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity


GenBank ID	NC_000017
	NM_003954
	NP_003945
	NT_010783
	NW_926839
	AC_000060
	AC003963
	AC008105
	DQ314874
	ABC40733
	AK131438
	BAD18584
	BC022296
	BC035576
	AAH35576
	CR749592
	CAH18391
	Y10256
	CAA71306
	Q68D39
	Q6ZMZ1
	Q8IYN1
	Q99558
	NC_000077
	NM_016896
	NP_058592
	NT_165773
	NW_000040
	NW_001030434
	AC_000033
	AL662804
	AY091549
	AAM34485
	AY091550
	AF143094
	AAD31512
	AK036200
	BAC29344
	AK172518
	BC107015
	AAI07016
	BG072756
	BG085546
	Q544K4
	Q9WUL6
	NC_005109
	XM_340918
	XP_340919
	NW_001084656
	XM_001081534
	XP_001081534
	NW_047340
	AC_000078


Source	Curated


LocusLink ID	9020
	53859
	360640


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	604655


Alias	HS
	NIK
	HSNIK
	FTDCR1B
	mitogen-activated protein kinase kinase kinase 14
	serine/threonine protein-kinase
	aly
	alymphoplasia
	protein kinase
	Nfkb inducing kinase
	NF kappa B-inducing kinase
	mitogen-activated protein kinase kinase kinase 14 (predicted)


GO ID	0005524
	0000166
	0005515
	0004672
	0004674
	0016740
	0006468
	0016301
	0004713


Swiss-Prot Accession	Q68D39
	Q6ZMZ1
	Q8IYN1
	Q99558
	Q544K4
	Q9WUL6


Unigene ID	Hs.404183
	Mm.158981