Protein : TLR3


Owner	Public
URN	urn:agi-llid:7098
Hugo ID	11849
Connectivity	241
Name	TLR3
Description	toll-like receptor 3
Notes	human homolog induces activation of NF-kappaB; mouse homolog plays a role in the production of inflammatory cytokines [RGD]


RGD ID	735171


MGI ID	2156367


Cell Localization	Plasma membrane


Group	Receptors
	signal transduction
	activation of NF-kappaB-inducing kinase
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	negative regulation of osteoclast differentiation
	positive regulation of interferon-alpha biosynthesis
	positive regulation of interferon-beta biosynthesis
	positive regulation of interferon-gamma biosynthesis
	activation of NF-kappaB transcription factor
	detection of virus
	cytokine production
	inflammatory response
	immune response
	innate immune response
	defense response to bacterium
	defense response
	hyperosmotic response
	response to virus
	membrane
	integral to membrane
	integral to plasma membrane
	double-stranded RNA binding
	receptor activity
	transmembrane receptor activity


Source	Curated


OMIM ID	603029


Alias	CD283
	toll-like receptor 3
	Toll-like receptor 3 isoform NT2-N
	AI957183