Protein : CHUK


Owner	Public
URN	urn:agi-llid:1147
Hugo ID	1974
Connectivity	418
Name	CHUK
Description	conserved helix-loop-helix ubiquitous kinase (predicted)
Notes	This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.


RGD ID	1306661


MGI ID	99484


Pathway	TNFR2 signaling
	Toll-Like Receptor pathway


Group	Kinases
	I-kappaB phosphorylation
	osteoclast differentiation
	protein amino acid phosphorylation
	morphogenesis
	morphogenesis of an epithelial sheet
	odontogenesis (sensu Vertebrata)
	immune response
	cytoplasm
	nucleotide binding
	protein binding
	ATP binding
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity
	IkappaB kinase activity
	receptor signaling protein serine-threonine kinase activity


Source	Curated


OMIM ID	600664


Alias	IKK1
	IKKA
	IKBKA
	TCF16
	NFKBIKA
	IKK-alpha
	conserved helix-loop-helix ubiquitous kinase
	IKK-a kinase
	I-kappa-B kinase 1
	I-kappa-B kinase-alpha
	IkB kinase alpha subunit
	conserved helix-loop ubiquitous kinase
	Nuclear factor NFkappaB inhibitor kinase alpha
	Chuk1
	IKK-1
	IKK[a]
	AI256658
	IKKalpha
	IKK 1
	IKK alpha
	IkappaB kinase alpha
	conserved helix-loop-helix ubiquitous kinase (predicted)