Protein : MYD88

Owner Public
URN urn:agi-llid:4615
Hugo ID 7562
Connectivity 320
Name MYD88
Description myeloid differentiation primary response gene 88
Notes an adaptor protein which binds toll-like receptors and links them to other downstream signalling molecules [RGD]

RGD ID 735043

MGI ID 108005

Cell Localization Plasma membrane

Pathway NF-kB Signaling
Toll-Like Receptor pathway
IL1R -> NF-kB signaling pathway
IL1R -> STAT3 signaling pathway
TLR1/2 -> NF-kB signaling pathway
TLR2/4/5/7/9 -> AP-1 signaling pathway
TLR2/6 -> AP-1 signaling pathway
TLR2/6 -> NF-kB signaling pathway
TLR4 -> IRF3/7 signaling pathway
TLR4/5/7/9 -> NF-kB signaling pathway

Group Receptors
signal transduction
cell surface receptor linked signal transduction
Toll signaling pathway
transmembrane receptor protein serine-threonine kinase signaling pathway
I-kappaB kinase-NF-kappaB cascade
positive regulation of I-kappaB kinase-NF-kappaB cascade
interferon type I biosynthesis
positive regulation of tumor necrosis factor-alpha biosynthesis
inflammatory response
immune response
immunoglobulin mediated immune response
response to virus
membrane
cytoplasm
signal transducer activity
protein binding
death receptor binding
Toll binding
transmembrane receptor activity

GenBank ID NC_000003
NM_002468
NP_002459
NT_022517
NW_921651
AC_000046
AP006309
AK097983
BAC05209
AK124685
AL832906
BC013589
AAH13589
BP242808
BP339466
BT007376
AAP36040
BX537602
U70451
AAB49967
U84408
AAC50954
Q53XS7
Q8N1J2
Q99836
NC_000075
NM_010851
NP_034981
NT_039482
NW_000361
NW_001030922
AC_000031
AC128702
U89023
AAB83958
X86457
AK090107
BAC41096
AK150083
BAE29292
AK151748
BAE30658
AK152596
BAE31345
AK152935
BAE31609
AK167929
BAE39933
AK186240
BC005591
AAH05591
BC051075
BC058787
AAH58787
BG072146
BG084982
U84409
AAC53013
X51397
CAA35762
P22366
NC_005107
NM_198130
NP_937763
NW_001084876
NW_047803
AC_000076
AY191270
AAO91937
BC097266
AAH97266
Q4QRC0

Source Curated

LocusLink ID 4615
17874
301059

Organism Homo sapiens
Mus musculus
Rattus norvegicus

OMIM ID 602170

Alias myeloid differentiation primary response gene (88)
myeloid differentiation primary response gene 88

GO ID 0005123
0005515
0004871
0004888
0007166
0006954
0043123
0016020
0007249
0016064
0006955
0045351
0042535
0009615
0007165
0007178
0005737
0005121
0008063

Swiss-Prot Accession Q53XS7
Q8N1J2
Q99836
P22366
Q4QRC0

Unigene ID Hs.82116
Mm.213003
Rn.37341