Protein : TRAF6


Owner	Public
URN	urn:agi-llid:7189
Hugo ID	12036
Connectivity	409
Name	TRAF6
Description	Tnf receptor-associated factor 6 (predicted)
Notes	The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.


RGD ID	1306853


MGI ID	108072


Pathway	LT-alpha
	Jnk-mapk
	p38 MAPK
	Eda-A2
	TROY
	RANKL
	FasL
	BAFF
	APRIL
	VEGI
	TNF-alpha
	NF-kB Signaling
	Toll-Like Receptor pathway
	IL1
	CD40L
	IL18
	B-cell receptor -> NF-kB signaling pathway
	IL1R -> NF-kB signaling pathway
	IL1R -> STAT3 signaling pathway
	T-cell receptor -> NF-kB signaling pathway
	CD22/72 -> NF-kB signaling pathway
	TLR1/2 -> NF-kB signaling pathway
	TLR2/4/5/7/9 -> AP-1 signaling pathway
	TLR2/6 -> AP-1 signaling pathway
	TLR2/6 -> NF-kB signaling pathway
	TLR4/5/7/9 -> NF-kB signaling pathway
	TNFRs -> AP-1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	TNFRs -> CREB1 signaling pathway
	DDR1 -> NF-kB signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	TNFRs -> NF-kB signaling pathway
	NGFR -> AP-1 signaling pathway
	TNFRs -> TP53 signaling pathway
	NGFR -> CEBPB signaling pathway
	NGFR -> CREB1 signaling pathway
	NGFR -> ELK1-SRF signaling pathway
	NGFR -> ELK4-SRF signaling pathway
	NGFR -> NF-kB signaling pathway
	NGFR -> TP53 signaling pathway
	TNFRSF5 -> RB1-E2F1 signaling pathway
	EDARs -> AP-1 signaling pathway
	EDARs -> LEF1 signaling pathway
	EDARs -> NF-kB signaling pathway
	TNFRSF5/13B -> NFATC1 signaling pathway


Group	Ubiquitin ligases
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	cell development
	myeloid dendritic cell differentiation
	regulation of apoptosis
	positive regulation of interleukin-12 biosynthesis
	positive regulation of interleukin-6 biosynthesis
	ubiquitin cycle
	organ morphogenesis
	odontogenesis (sensu Vertebrata)
	ossification
	regulation of immunoglobulin secretion
	immune response
	antigen processing and presentation of exogenous peptide antigen via MHC class II
	T-helper 1 type immune response
	signal transducer activity
	protein binding
	metal ion binding
	zinc ion binding
	receptor activity


Source	Curated


OMIM ID	602355


Alias	RNF85
	MGC:3310
	TNF receptor-associated factor 6
	AI851288
	2310003F17Rik
	C630032O20Rik
	Tnf receptor-associated factor 6 (predicted)


Swiss-Prot Accession	Q9Y4K3
	P70196


Unigene ID	Hs.591983
	Mm.292729