Protein : TLR9
Owner Public
URN urn:agi-llid:54106
Hugo ID 15633
Connectivity 223
Name TLR9
Description toll-like receptor 9
Notes The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
MGI ID 1932389
Cell Localization Plasma membrane
Pathway Toll-Like Receptor pathway
TLR2/4/5/7/9 -> AP-1 signaling pathway
TLR4/5/7/9 -> NF-kB signaling pathway
Group Receptors
positive regulation of interferon-alpha biosynthesis
positive regulation of interferon-beta biosynthesis
positive regulation of interferon-gamma biosynthesis
inflammatory response
immune response
defense response to bacterium
response to virus
extracellular region
membrane
plasma membrane
integral to membrane
extracellular space
siRNA binding
receptor activity
transmembrane receptor activity
GenBank ID NC_000003
NM_017442
NP_059138
NT_022517
NW_921651
AC_000046
NM_138688
NP_619633
AC097637
AB045180
BAB19259
AF245704
AAF78037
AF246972
AAG01734
AF246973
AAG01735
AF246974
AAG01736
AF259262
AAF72189
AF259263
AAF72190
AY359085
AAQ89443
BC032713
AAH32713
Q9NR96
NC_000075
NM_031178
NP_112455
NT_039477
NW_001030918
AC_000031
AC164430
AY649790
AAU04980
AY649791
AAU04981
AB045181
BAB19260
AF314224
AAK28488
AF348140
AAK29625
Q9EQU3
Source Curated
LocusLink ID 54106
81897
Organism Homo sapiens
Mus musculus
OMIM ID 605474
Alias CD289
toll-like receptor 9
GO ID 0035197
0004888
0042742
0006954
0045356
0045359
0045078
0005576
0016021
0016020
0004872
0006955
0009615
0005615
0005886
Swiss-Prot Accession Q9NR96
Q9EQU3
Unigene ID Hs.87968
Mm.44889