Protein : TLR4


Owner	Public
URN	urn:agi-llid:7099
Hugo ID	11850
Connectivity	729
Name	TLR4
Description	toll-like receptor 4
Notes	receptor that functions as the major upstream sensor for hemorrhagic shock and lipopolysaccharide [RGD]


RGD ID	3870


MGI ID	96824


Cell Localization	Plasma membrane


Group	Receptors
	signal transduction
	I-kappaB kinase-NF-kappaB cascade
	activation of NF-kappaB-inducing kinase
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	negative regulation of osteoclast differentiation
	positive regulation of interleukin-1 biosynthesis
	positive regulation of interleukin-12 biosynthesis
	positive regulation of interleukin-13 biosynthesis
	positive regulation of interleukin-6 biosynthesis
	detection of bacterium
	detection of fungus
	metabolism
	inflammatory response
	macrophage activation
	mast cell activation
	immune response
	innate immune response
	T-helper 1 type immune response
	membrane
	integral to membrane
	integral to plasma membrane
	lipopolysaccharide receptor complex
	catalytic activity
	protein binding
	lipopolysaccharide binding
	receptor activity
	transmembrane receptor activity


Source	Curated


OMIM ID	603030


Alias	TOLL
	CD284
	hToll
	toll-like receptor 4
	homolog of Drosophila toll
	Lps
	Ly87
	Ran/M1
	Rasl2-8
	lipopolysaccharide response