ProtModification :


Mechanism	phosphorylation
Owner	Public
URN	urn:agi-ProtModification:inout-urn:agi-llid:9020:out-urn:agi-llid:1147::positive
Entities	MAP3K14 --+> CHUK
References	3
Connectivity	2
Effect	positive


MedLine Reference	15208311:1207
Sentence	Coexpression of TNAP blocks TNF-alpha-induced NIK kinase activity to phosphorylate IKK1 ( Fig. 4 B , left lower panel ).
Journal	J. Biol. Chem
Journal Reference	v279 i34 p35975 (2004)
Journal Link	http://www.jbc.org/cgi/content/full/279/34/35975
CellLineName	HEK293t
Source	Curated


MedLine Reference	9461607:1032
Sentence	TRAF2 mediates NF-kappaB activation via the recruitment of the serine/threonine kinase NIK ( 23 ), which can in turn activate CHUK, an IkappaB-specific kinase that triggers IkappaB degradation ( 25 , 26 ).
Source	Curated


MedLine Reference	3615571880
Sentence	Ikk-alpha interacts with NIK. This interaction was modeled on a demonstrated interaction between human IKK-alpha and NIK from an unspecified species
Source	Curated