ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:4214:out-urn:agi-llid:1147::positive
Entities MAP3K1 --+> CHUK
References 23
Connectivity 2
Effect positive
MedLine Reference 10593965:1049
Sentence Both NIK and MEKK1 are able to phosphorylate IKKalpha and IKKeta leading to their activation ( 29 , 30 ).
Journal J. Biol. Chem
Journal Reference v274 i51 p36631 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/51/36631
Organism mouse
Source Curated
MedLine Reference 11278990:1220
Sentence NIK and MEK kinase 1 can phosphorylate IKK1 and IKK2 with some specificity; whereas MEK kinase 1 preferentially phosphorylates IKK2, NIK can act over both IKKs ( 30 , 49 , 52 ).
Journal J. Biol. Chem
Journal Reference v276 i19 p15854 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/19/15854
Organism mouse
Source Curated
MedLine Reference 11562344:1139
Sentence Similarly, although MEKK1 can phosphorylate both IKKalpha and IKKeta in vitro, mekk1 -/- mouse embryonic fibroblasts (MEFs) display normal NF-kappaB activation in response to TNFalpha (Yujiri et al. 2000 ).
Journal Genes & Dev
Journal Reference v15 i18 p2321 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/18/2321
Source Curated
CellType fibroblast
MedLine Reference 11479295:1244
Sentence Upstream kinases in the NF-kappaB pathway that include MEKK1 and NF-kappaB-inducing kinase phosphorylate IKKalpha on serines 176 and 180 and IKKeta on serines 177 and 181 in their kinase domain.
Journal J. Biol. Chem
Journal Reference v276 i38 p35693 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/38/35693
Organism mouse
Tissue alveola
Source Curated
MedLine Reference 10878013:1214
Sentence Previous studies have shown that MEKK1 , an upstream activator of both the JNK and p38 MAP kinase pathways, phosphorylates both IKKalpha and IKKeta, and it acts in conjunction with the NF-kappaB-inducing kinase to synergistically activate the IKK complex ( 42 , 43 ).
Journal J. Biol. Chem
Journal Reference v275 i36 p27858 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/36/27858
Source Curated
Journal Cell
Journal Reference v93 i5 p875 (1998)
Journal Link http://www.cell.com/cgi/content/full/93/5/875
CellLineName COS
Source Curated
MedLine Reference 10747982:1132
Journal J. Biol. Chem
Journal Reference v275 i19 p14752 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/19/14752
CellLineName COS
Organism mouse
Source Curated
MedLine Reference 10574930:1124
Journal J. Biol. Chem
Journal Reference v274 i49 p34657 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/49/34657
CellLineName TK
Organism mouse
Source Curated
MedLine Reference 10206979:1125
Journal J. Biol. Chem
Journal Reference v274 i17 p11667 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/17/11667
CellLineName HeLa
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 10843878:1233
Journal Heart Circul
Journal Reference v278 i6 pH1823 (2000)
Journal Link http://ajpheart.physiology.org/cgi/content/full/278/6/H1823
Organism bovine
Source Curated
MedLine Reference 9520401:1156
Journal PNAS
Journal Reference v95 i7 p3537 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/7/3537
CellLineName 293
Organism mouse
Source Curated
MedLine Reference 10713178:1146
Journal Mol. Cell. Biol
Journal Reference v20 i7 p2556 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/7/2556
CellLineName HeLa
Source Curated
MedLine Reference 10594023:1262
Journal Mol. Cell. Biol
Journal Reference v20 i1 p205 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/1/205
Source Curated
MedLine Reference 9689078:5
Source Curated
MedLine Reference 11116146:1042
Journal J. Biol. Chem
Journal Reference v276 i12 p8865 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/12/8865
Source Curated
MedLine Reference 10779525:1171
Journal J. Biol. Chem
Journal Reference v275 i26 p19693 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/26/19693
CellLineName 293
Organism mouse
Source Curated
MedLine Reference 10567421:1041
Journal J. Biol. Chem
Journal Reference v274 i48 p34417 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/48/34417
CellLineName TAX(+
Source Curated
MedLine Reference 10187861:1256
Journal J. Biol. Chem
Journal Reference v274 i15 p10641 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/15/10641
Source Curated
MedLine Reference 11445542:1233
Journal Genes & Dev
Journal Reference v15 i13 p1674 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/13/1674
Organism C-elegans
Source Curated
MedLine Reference 10356400:1027
Journal EMBO
Journal Reference v18 i11 p3044 (1999)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/18/11/3044
Source Curated
MedLine Reference 12432072:1029
Journal Cell Sci
Journal Reference v115 i24 p4843 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/115/24/4843
Source Curated
MedLine Reference 10962033:1160
Journal PNAS
Journal Reference v97 i19 p10494 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/19/10494
Source Curated
MedLine Reference 10852963:1209
Journal PNAS
Journal Reference v97 i13 p7272 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/13/7272
Organism mouse
Source Curated
CellType macrophage