ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:4214:out-urn:agi-llid:3551::positive
Entities MAP3K1 --+> IKBKB
References 10
Connectivity 2
Effect positive
MedLine Reference 9630230:4
Sentence Furthermore, recombinant MEKK1 stimulates IKKbeta phosphorylation of IkappaB alpha.
Source Curated
MedLine Reference 11278990:1220
Sentence NIK and MEK kinase 1 can phosphorylate IKK1 and IKK2 with some specificity; whereas MEK kinase 1 preferentially phosphorylates IKK2, NIK can act over both IKKs ( 30 , 49 , 52 ).
Journal J. Biol. Chem
Journal Reference v276 i19 p15854 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/19/15854
Organism mouse
Source Curated
MedLine Reference 10669746:1023
Sentence In turn, activation of IKK is mediated by phosphorylation through NF-kappaB-inducing kinase, which acts preferentially over IKK1, and MEK kinase 1 (MEKK1), which phosphorylates IKK2 ( 6 , 30 ).
Journal Mol. Cell. Biol
Journal Reference v20 i5 p1692 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/5/1692
Organism mouse
Source Curated
CellType macrophage
MedLine Reference 10206979:1125
Sentence LPS-induced Activation of IKK-2 and TNF-alpha Promoter Activity Is Blocked by Kinase-defective Mutants of NIK and MEKK1-- NIK and MEKK1 can activate IKK-1 or IKK-2 in HeLa cells and fibroblasts ( 34 , 37 , 39 , 42 ).
Journal J. Biol. Chem
Journal Reference v274 i17 p11667 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/17/11667
CellLineName HeLa
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 10574930:1124
Sentence Because FK506 induces the phosphorylation of IkappaBalpha at Ser-32, we next examined the effects of FK506 on the activity of IKK , the recently cloned protein kinase that preferentially phosphorylates Ser-32 and Ser-36 of IkappaBalpha ( 10-14 ). 293 and L-TK cells transfected with an IKK-2 expression vector (pFlag-IKK-2) were stimulated with IL-1 or FK506, whereas cells cotransfected with an expression vector encoding truncated and constitutively active forms of MEKK (pHA-Delta MEKK ) served as positive controls, as it is known that Delta MEKK activates both IKK-1 and IKK-2 ( 29 , 30 ).
Journal J. Biol. Chem
Journal Reference v274 i49 p34657 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/49/34657
CellLineName TK
Organism mouse
Source Curated
MedLine Reference 11369754:5
Source Curated
MedLine Reference 10758165:1229
Journal PNAS
Journal Reference v97 i9 p4615 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/9/4615
Source Curated
CellType t cell
MedLine Reference 10092768:6
CellLineName JURKAT
Source Curated
MedLine Reference 12167626:10
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 9689078:5
Source Curated