Protein : CASP8


Owner	Public
URN	urn:agi-llid:841
Hugo ID	1509
Connectivity	1126
Name	CASP8
Description	caspase 8
Notes	member of the cysteine-aspartic acid protease (caspase) familythat mediates the terminal stage of apoptosis; involved in apoptosis induced by Fas and other stimuli [RGD]


RGD ID	620945


MGI ID	1261423


Cell Localization	Nucleus
	Mitochondria


Pathway	LT-alpha
	LIGHT
	FAS signaling
	Eda-A2
	OX-40L
	RANKL
	FasL
	Eda-A1
	Caspases
	CD30L
	BAFF
	CD27L
	APRIL
	Mitochondrial control of Apoptosis
	TRAIL
	TNF-alpha signaling
	Death receptor signaling
	TNFR1 signaling
	VEGI
	TNF-alpha
	Inhibition of Apoptosis
	DR3 and DR4-5 pathways
	LT-beta
	GITR Ligand
	4-1BB ligand
	CD40L
	TWEAK
	Apoptosis
	TNFRSF6 -> FOXO3A signaling pathway
	Copy of 'Apoptosis'
	Apoptosis2
	Apoptosis2


Group	Proteases
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	macrophage differentiation
	apoptosis
	apoptotic program
	regulation of apoptosis
	proteolysis
	neural tube formation
	heart development
	angiogenesis
	cytoplasm
	mitochondrion
	Noc1p-Noc2p complex
	nucleus
	cytoskeleton
	signal transducer activity
	protein binding
	identical protein binding
	hydrolase activity
	peptidase activity
	cysteine-type peptidase activity
	caspase activity


Source	Curated


Alias	CAP4
	MACH
	MCH5
	FLICE
	MGC78473
	caspase 8
	procaspase-8
	procaspase-8L
	cysteine protease
	Mch5 isoform alpha
	MACH-alpha-1/2/3 protein
	MACH-beta-1/2/3/4 protein
	FADD-homologous ICE/CED-3-like protease
	caspase 8, apoptosis-related cysteine protease
	Caspase-8
	Fas-linked ICE-like protease