Protein : SOS1
Owner Public
URN urn:agi-llid:6654
Hugo ID 11187
Connectivity 566
Name SOS1
Description Son of sevenless homolog 1 (Drosophila)
Notes RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]
RGD ID 1310949
MGI ID 98354
Pathway LT-alpha
p40 MAPK
HGF
Insulin Receptor Signaling
RANKL
Antiapoptotic Pathways From IGF-1R
Insulin pathway
TNF-alpha
MAPK-ERK in Growth and Differentiation
G-protein Coupled Receptor signaling
PTEN signaling
CREB signaling
EPHA2
NGF signaling
Integrin Signaling
AGTR1 -> ELK1-SRF signaling pathway
PTPRC -> BCL6 signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
EDG2 -> ELK4-SRF signaling pathway
AGTR1 -> TP53 signaling pathway
AGTR2 -> CREB1 signaling pathway
EGFR -> AP-1 signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
AGTR2 -> TP53 signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> SMAD1 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
NTRKs -> TP53 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
IGF1R -> MYC signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
PECAM1 -> SP1 signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> SP1 signaling pathway
EPOR -> ELK1-SRF signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
EPOR -> FOS signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
SELE -> ELK4-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
T-cell receptor -> AP-1 signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
IL6R -> CEBPB signaling pathway
FGFRs -> RUNX2 signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
ITGB1 -> SREBF2 signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
GFRs -> NCOR2 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CHRNA7 -> CREB1 signaling pathway
ADRA1B -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
LEPR -> ELK1-SRF signaling pathway
ADRA1B -> STAT3 signaling pathway
LEPR -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> CREB1 signaling pathway
MPL -> SP1 signaling pathway
MPL -> SPI1 signaling pathway
NCAM1 -> CREB1 signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
NCAM1 -> ELK4-SRF signaling pathway
NCAM1 -> MYC signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGTR1 -> CREB1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Group Gtpase regulators
Ph
signal transduction
intracellular signaling cascade
small GTPase mediated signal transduction
Ras protein signal transduction
regulation of small GTPase mediated signal transduction
regulation of Rho protein signal transduction
intracellular
protein binding
DNA binding
Rho GTPase activator activity
guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
GenBank ID NC_000002
NM_005633
NP_005624
NT_022184
NW_927719
AC_000045
AC019171
AAX93186
AC092672
AAY24202
AF106953
AAF04460
AF441482
AAM22406
AB209140
BAD92377
L13857
AAA35913
Q07889
Q53SF8
Q59GG9
Q8NIA3
Q9UKX9
NC_000083
NM_009231
NP_033257
NT_039649
NW_000133
NW_001030622
AC_000039
AC161447
AF094674
AF094675
AF094676
AF094677
AF094679
AAF08009
AF233591
AAF42937
AY902349
AAY21059
AK140310
BAE24327
BG065298
Z11574
CAA77662
Z11578
CAA77665
Q62245
NC_005105
XM_233820
XP_233820
NW_001084845
XM_001062567
XP_001062567
NW_047754
AC_000074
BC100642
AAI00643
Source Curated
LocusLink ID 6654
20662
313845
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 182530
135300
Alias GF1
HGF
GGF1
GINGF
son of sevenless homolog 1
alternate SOS1
gingival fibromatosis
gingival fibromatosis, hereditary, 1
son-of-sevenless 1
ras guanine exchange factor
son of sevenless like-protein 1
guanine nucleotide releasing factor
Son of sevenless homolog 1 (Drosophila)
GO ID 0003677
0005088
0005100
0005089
0005515
0007265
0035023
0007165
0005622
0005085
0007242
0051056
0007264
Swiss-Prot Accession Q07889
Q53SF8
Q59GG9
Q8NIA3
Q9UKX9
Q62245
Unigene ID Hs.278733
Mm.60975
Rn.161894