Protein : TNF


Owner	Public
URN	urn:agi-llid:7124
Hugo ID	11892
Connectivity	7876
Name	TNF
Description	tumor necrosis factor (TNF superfamily, member 2)
Notes	acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response [RGD]


RGD ID	3876


MGI ID	104798


Cell Localization	Extracellular


Pathway	DR6
	TNF-alpha signaling
	Death receptor signaling
	TNFR1 signaling
	TNF-alpha
	Inhibition of Apoptosis
	NF-kB Signaling
	Apoptosis
	TNFRs -> AP-1 signaling pathway
	TNFRs -> ATF2 signaling pathway
	TNFRs -> CREB1 signaling pathway
	TNFRs -> ELK1-SRF signaling pathway
	TNFRs -> ELK4-SRF signaling pathway
	TNFRs -> NF-kB signaling pathway
	TNFRs -> TP53 signaling pathway
	TNFRSF1A -> AP-1 signaling pathway
	TNFRSF1A -> ATF2 signaling pathway
	TNFRSF1A -> CREB1 signaling pathway
	TNFRSF1A -> ELK1-SRF signaling pathway
	TNFRSF1A -> ELK4-SRF signaling pathway
	TNFRSF1A -> STAT1 signaling pathway
	TNFRSF1A -> STAT3 signaling pathway
	TNFRSF1A -> STAT5A signaling pathway
	TNFRSF1A -> STAT5B signaling pathway
	TNFRSF1A -> STAT6 signaling pathway
	TNFRSF1A -> TP53 signaling pathway
	Aquaporin
	Copy of 'Apoptosis'
	Apoptosis2
	Apoptosis2


Group	Ligands
	development
	leukocyte adhesion
	cell-cell signaling
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of JNK cascade
	osteoclast differentiation
	regulation of osteoclast differentiation
	cell proliferation
	apoptosis
	transformed cell apoptosis
	anti-apoptosis
	induction of apoptosis
	induction of apoptosis by extracellular signals
	induction of apoptosis via death domain receptors
	leukocyte migration
	cellular extravasation
	regulation of cell proliferation
	positive regulation of cell proliferation
	glucose metabolism
	regulation of protein amino acid phosphorylation
	positive regulation of translational initiation by iron
	negative regulation of transcription from RNA polymerase II promoter
	positive regulation of transcription
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	activation of NF-kappaB transcription factor
	negative regulation of glucose import
	organ morphogenesis
	regulation of immunoglobulin secretion
	inflammatory response
	immune response
	humoral immune response
	defense response to bacterium
	defense response
	response to virus
	response to wounding
	membrane
	soluble fraction
	secretory granule
	plasma membrane
	integral to membrane
	integral to plasma membrane
	extracellular space
	protein binding
	cytokine activity
	tumor necrosis factor receptor binding


Source	Curated


Alias	DIF
	TNFA
	TNFSF2
	TNF-alpha
	DASS-280D8.2
	tumor necrosis factor alpha
	cachectin
	APC1 protein
	OTTHUMP00000037669
	TNF, monocyte-derived
	TNF, macrophage-derived
	TNF superfamily, member 2
	Tnfsf1a
	TNFalpha
	MGC151434
	TNF alpha
	tumor necrosis factor-alpha
	RATTNF
	MGC124630
	tumor necrosis factor superfamily, member 2
	Tumor necrosis factor alpha (cachetin)
	tumor necrosis factor, alpha (cachetin)
	tumor necrosis factor superfamily member 2
	tumor necrosis factor superfamily, member 2


MedScan ID	7124


LocatorString	pmquery:aquaporin