DirectRegulation :

Owner Public
URN urn:agi-DirectRegulation:inout-urn:agi-llid:841:out-urn:agi-llid:7186::positive
Entities CASP8 --+> TRAF2
References 4
Effect positive
Connectivity 2
Sentence In the second cascade, TRAF2 and RIP are activated by FADD , Casper , and caspase-8.
Journal J. Biol. Chem
Source Curated
Journal Reference v275 i15 p10838 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/15/10838
Organism plant
MedLine Reference 10753878:1192
Sentence Analysis of the native TNF signaling complex revealed the recruitment of RIP, TRADD, and TRAF2 but not FADD or caspase-8.
Journal J. Biol. Chem
Source Curated
Journal Reference v278 i28 p25534 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/28/25534
MedLine Reference 12721308:1017
Sentence F and G , TRAF1 and TRAF2 interact with caspase-8 prodomain (residues 1-180), protease domain (residues 217-479), and MRITeta1 isoform.
Journal J. Biol. Chem
Source Curated
Journal Reference v274 i27 p19211 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/27/19211
Organism mouse
MedLine Reference 10383428:1172
Sentence To address if TRAF2 forms a complex with caspase 8 via binding to FLIP(p43), 293T cells were transfected with FLAG-procaspase 8 together with either VSV-FLIP(L) or VSV-FLIP(p43), and anti-FLAG beads were used for immunoprecipitation (Fig. 6C ).
CellLineName 293T
Journal Mol. Cell. Biol
Source Curated
Journal Reference v24 i7 p2627 (2004)
Journal Link http://mcb.asm.org/cgi/content/full/24/7/2627
Organism Mus musculus
MedLine Reference 15024054:1190