DirectRegulation :

Owner Public
URN urn:agi-DirectRegulation:inout-urn:agi-llid:7186:out-urn:agi-llid:841::negative
Entities TRAF2 ---| CASP8
References 10
Effect negative
Connectivity 2
Sentence Caspase-8 could coimmunoprecipitate TRAF1, -2, -3, and -5 but failed to coimmunoprecipitate I-TRAF (Fig. 4 , A-C ).
CellLineName 293T
Journal J. Biol. Chem
Source Curated
Journal Reference v274 i27 p19211 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/27/19211
Organism mouse
MedLine Reference 10383428:1145
Sentence A recent report indicated that the expression of TRAF1, TRAF2, c-IAP-1, and c-IAP-2 suppresses apoptosis by blocking activation of the initiator caspase, caspase-8 ( 42 ).
Journal PNAS
Source Curated
Journal Reference v96 i6 p2994 (1999)
Journal Link http://www.pnas.org/cgi/content/full/96/6/2994
Organism mouse
MedLine Reference 10077625:1195
Sentence Deng et al. ( 33 ) reported that Smac makes c-IAP1 dissociate from TRAF2, which in turn releases the inhibition of caspase-8 activation by TRAF2-c-IAP1 complex.
CellLineName 293T
Journal J. Biol. Chem
Source Curated
Journal Reference v279 i17 p16963 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/17/16963
MedLine Reference 14960576:1195
Sentence Furthermore, the recruitment of c-IAP1 and c-IAP2 to the TNFR complex through interactions with TRAF1 or TRAF2 inhibits the activation of the initiator caspase, caspase-8 ( 22 ).
Journal AJRCMB
Source Curated
Journal Reference v22 i2 p147 (2000)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/22/2/147
MedLine Reference 10657934:1053
Sentence NF-kappaB activation in turn induces expression of c-IAP-1 and -2, which, through their association with TRAF1 and 2, inhibit the activation of caspase-8, curbing the apoptotic signal ( Wang et al ., 1998 ).
Journal EMBO
Source Curated
Journal Reference v19 i14 p3597 (2000)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/19/14/3597
Organism rat
MedLine Reference 10899114:1031
Sentence Antiapoptotic target genes of NF-kappaB include the IAP family of caspase inhibitory proteins, TRAF1 and TRAF2, which are thought to suppress caspase-8 activation, Bfl1/A1, Bcl-XL, and inducible nitric oxide synthetase.
Journal EBM
Source Curated
Journal Reference v228 i9 p995 (2003)
Journal Link http://www.ebmonline.org/cgi/content/full/228/9/995
MedLine Reference 14530507:1230
Sentence Therefore, RIP, TRAF2, and FADD play disparate roles in H2O2-induced cell death versus TNF-induced apoptosis, which depends on the activation of a caspase cascade initiated by caspase-8 activation ( 3 , 4 ).
CellLineName mef
Journal Mol. Cell. Biol
Source Curated
Journal Reference v24 i13 p5914 (2004)
Journal Link http://mcb.asm.org/cgi/content/full/24/13/5914
Organism Mus musculus
MedLine Reference 15199146:1090
Sentence Activation of nuclear factor kappaB (NF-kappaB), a transcription factor integral to IL-1eta signal transduction, has recently been shown to augment expression of TNFR-associated factor 1 (TRAF1) and TRAF2, along with cIAP-1 and cIAP-2, and coordinately suppress caspase-8 activation and apoptosis ( 27 ).
Journal AJRCMB
Source Curated
Journal Reference v26 i1 p58 (2002)
Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/26/1/58
MedLine Reference 11751204:1238
CellLineName C33A
Source Curated
Organism mouse
MedLine Reference 15592525:7
Source Curated
Organism mouse
MedLine Reference 15024054:8