Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:841:out-urn:agi-cellproc:apoptosis::positive
Entities CASP8 --+> apoptosis
References 348
Connectivity 2
MedLine Reference 14624380:4
Sentence Although IAPs do not bind or inhibit caspase-8, they do bind to and inhibit its substrate caspase-3, thus arresting the cascade of proteolysis and providing protection from Fas/caspase-8-induced apoptosis (Deveraux et al. 1997 , 1998 ; Roy et al. 1997 ).
Tissue mesothelial
Journal AJRCMB
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Organ colon
Organism frog
Source Curated
CellType chondrocyte
CellLineName ags
MedLine Reference 10096572:1166
Sentence Caspases 1, 2, 4, 5, 8, and 10, which have long prodomains, are implicated in targeting and regulating apoptosis.
Journal Cancer Res
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Organism mouse
Source Curated
CellType monocyte
CellLineName THP I
MedLine Reference 12010809:1165
Sentence Interestingly, caspase-8L significantly inhibited caspase-8a-mediated apoptosis by approximately 30% even at a ratio of 0.125 (caspase-8L/caspase-8a) (Figure 5 C, ).
Journal Blood
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Source Curated
MedLine Reference 11435307:1011
Sentence Moreover, IDV did not inhibit activation of caspases-1, -3, -4, -5, -9, and -8 in lysates of Jurkat T cells undergoing Fas-induced apoptosis.
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CellType t cell
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Sentence Because caspase-8 is the most proximal caspase involved in receptor-mediated apoptosis, the previous data implicated other mechanisms responsible for caspase-8 processing.
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Sentence Thus, in contrast to the death receptor-mediated activation of apoptosis, caspase-8 appears to function as an amplifying executioner caspase in drug-induced B cell apoptosis.
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CellType b cell
MedLine Reference 15778357:0
Source Curated
CellType t cell
MedLine Reference 15576458:5
Source Curated
CellType chondrocyte
MedLine Reference 15083198:6
Tissue mesothelial
Source Curated
MedLine Reference 12485124:10
Tissue epithelia
Organ gastric
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Organ brain
Organism rat
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Organism mouse
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CellType t cell
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Tissue endothelial
Organ umbilical vein
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MedLine Reference 11156370:1022
Journal Cancer Res
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Source Curated
CellType lymphocyte
MedLine Reference 10969767:1010
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Source Curated
MedLine Reference 10850456:1123
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Organism mouse
Source Curated
MedLine Reference 11906168:0
Source Curated
MedLine Reference 11855814:0
Source Curated
MedLine Reference 11593384:2
Source Curated
MedLine Reference 11410792:1
Source Curated
MedLine Reference 11145953:0
Source Curated
MedLine Reference 11238216:9
Source Curated
MedLine Reference 9971775:7
Source Curated
MedLine Reference 11107128:5
Source Curated
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Source Curated
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Source Curated
MedLine Reference 10812970:1
Source Curated
MedLine Reference 11848481:3
Source Curated
CellLineName U373 MG
MedLine Reference 11598198:5
Source Curated
CellLineName BL41
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Source Curated
CellLineName ATL
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Source Curated
CellLineName MT
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Journal EBM
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Source Curated
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Tissue islet
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Organism bovine
Source Curated
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Journal Cell
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Source Curated
MedLine Reference 12865435:1233
Journal Cell Sci
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Source Curated
CellLineName TF1
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Tissue endothelial
Journal Cell Sci
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Source Curated
MedLine Reference 11739649:1338
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MedLine Reference 10437917:1225
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Organism C-elegans
Source Curated
MedLine Reference 11895859:1233
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Source Curated
MedLine Reference 10688869:1107
Journal Carcinogenesis
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Source Curated
MedLine Reference 12941843:1321
Journal Cancer Res
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Source Curated
MedLine Reference 12839956:1397
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Organism mouse
Source Curated
MedLine Reference 12670894:1117
Journal Cancer Res
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Source Curated
CellLineName HCT 116
MedLine Reference 12649185:1006
Journal Cancer Res
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Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/6/1254
Source Curated
MedLine Reference 12615731:1029
Journal Cancer Res
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Source Curated
CellLineName NB
MedLine Reference 15566642:0
Source Curated
MedLine Reference 15326164:7
Source Curated
MedLine Reference 14749474:7
Source Curated
MedLine Reference 12949717:1
Source Curated
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Source Curated
MedLine Reference 12711301:4
Source Curated
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Source Curated
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Source Curated
MedLine Reference 11877079:5
Source Curated
CellLineName K 562
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Source Curated
CellLineName PC-3
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Source Curated
CellLineName SGC 7901
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CellLineName C4
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CellLineName U 937
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Source Curated
CellLineName JURKAT
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CellLineName M1
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Source Curated
CellLineName KB
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Organism mouse
Source Curated
CellType hepatocyte
MedLine Reference 10744739:1026
Journal J. Biol. Chem
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Organism C-elegans
Source Curated
MedLine Reference 10734071:1144
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MedLine Reference 10722706:1157
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Organism mouse
Source Curated
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Source Curated
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Organ liver
Organism rat
Source Curated
MedLine Reference 10593992:1020
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Organism mouse
Source Curated
MedLine Reference 10187770:1107
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Organism C-elegans
Source Curated
CellLineName 293T
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Source Curated
MedLine Reference 10409188:1024
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Organism rat
Source Curated
MedLine Reference 10561604:1215
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Organism plant
Source Curated
MedLine Reference 12538625:1214
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Source Curated
CellLineName Ov2008
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Journal EMBO
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Source Curated
CellLineName JURKAT
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Journal EMBO
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Source Curated
MedLine Reference 12912912:1115
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CellLineName JURKAT
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Organism mouse
Source Curated
CellType fibroblast
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Source Curated
MedLine Reference 10527889:5
Source Curated
MedLine Reference 10830721:1
Source Curated
MedLine Reference 10568827:4
Source Curated
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Source Curated
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Source Curated
MedLine Reference 9840918:5
Source Curated
MedLine Reference 15705878:1
Source Curated
MedLine Reference 15662081:2
Source Curated
MedLine Reference 15531912:1
Source Curated
MedLine Reference 15467448:2
Source Curated
MedLine Reference 10894160:5
Source Curated
CellLineName JURKAT
MedLine Reference 10792984:5
Source Curated
CellLineName Intestine 407
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Source Curated
CellLineName LAMA84
MedLine Reference 15161936:5
Source Curated
CellLineName HL 60
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Source Curated
CellLineName HL 60
MedLine Reference 11514563:1114
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Organism mouse
Source Curated
CellLineName JURKAT
MedLine Reference 11507096:1159
Journal J. Biol. Chem
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Source Curated
MedLine Reference 11500509:1026
Journal J. Biol. Chem
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Organism mouse
Source Curated
MedLine Reference 11479302:1021
Journal J. Biol. Chem
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Organism mouse
Source Curated
MedLine Reference 11451944:1041
Journal J. Biol. Chem
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Source Curated
MedLine Reference 11431480:1022
Journal J. Biol. Chem
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Source Curated
CellLineName JURKAT
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Organism dog
Source Curated
CellLineName mdck
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Journal J. Biol. Chem
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Source Curated
CellLineName U 937
MedLine Reference 11278310:1141
Journal J. Biol. Chem
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Source Curated
MedLine Reference 10988287:1209
Journal J. Biol. Chem
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Organism mouse
Source Curated
MedLine Reference 10961984:1168
Journal J. Biol. Chem
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Source Curated
MedLine Reference 10899173:1238
Journal J. Biol. Chem
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Source Curated
MedLine Reference 10896673:1235
Journal J. Biol. Chem
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Source Curated
MedLine Reference 10837470:1018
Journal J. Biol. Chem
Journal Reference v275 i34 p25939 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/34/25939
Source Curated
MedLine Reference 10799503:1021
Journal J. Biol. Chem
Journal Reference v275 i19 p14248 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/19/14248
Source Curated
MedLine Reference 10777599:1030
Tissue egg
Journal J. Biol. Chem
Journal Reference v275 i17 p12978 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/17/12978
Organism drosophila
Source Curated
MedLine Reference 15371157:3
Source Curated
MedLine Reference 14519653:8
Source Curated
MedLine Reference 12198154:0
Source Curated
MedLine Reference 11894131:1
Source Curated
MedLine Reference 11555331:6
Source Curated
MedLine Reference 15579484:7
Source Curated
CellLineName ags
MedLine Reference 15452117:6
Source Curated
CellLineName ccrf-hsb-2
MedLine Reference 12929750:4
Source Curated
CellLineName HL 60
MedLine Reference 12706091:4
Source Curated
CellLineName SB
MedLine Reference 12161280:1
Source Curated
CellLineName HL 60
MedLine Reference 11599886:9
Source Curated
CellLineName A431
MedLine Reference 11277999:3
Source Curated
CellLineName JURKAT
MedLine Reference 12397080:1034
Journal J. Biol. Chem
Journal Reference v277 i51 p49644 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49644
Organism drosophila
Source Curated
MedLine Reference 12388546:1200
Journal J. Biol. Chem
Journal Reference v277 i51 p49504 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49504
Source Curated
MedLine Reference 12377771:1209
Journal J. Biol. Chem
Journal Reference v277 i50 p48913 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/50/48913
Organism yeast
Source Curated
MedLine Reference 12324452:1258
Tissue islet
Journal J. Biol. Chem
Journal Reference v277 i49 p47826 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/49/47826
Organ pancreas
Source Curated
CellType neutrophil
MedLine Reference 12200426:1046
Journal J. Biol. Chem
Journal Reference v277 i44 p42074 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/44/42074
Organism mouse
Source Curated
CellType neural
MedLine Reference 12198125:1036
Journal J. Biol. Chem
Journal Reference v277 i44 p41850 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/44/41850
Source Curated
MedLine Reference 12122017:1039
Tissue lymph
Journal J. Biol. Chem
Journal Reference v277 i38 p35097 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/38/35097
Organism drosophila
Source Curated
MedLine Reference 12121969:1042
Journal J. Biol. Chem
Journal Reference v277 i39 p36611 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/39/36611
Source Curated
CellLineName MCF7
MedLine Reference 12107169:1026
Journal J. Biol. Chem
Journal Reference v277 i37 p34343 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/37/34343
Source Curated
MedLine Reference 12077131:1026
Journal J. Biol. Chem
Journal Reference v277 i35 p31381 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/35/31381
Organism rat
Source Curated
MedLine Reference 12065591:1036
Journal J. Biol. Chem
Journal Reference v277 i37 p34217 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/37/34217
Organ brain
Organism mouse
Source Curated
CellType neural
MedLine Reference 12063258:1015
Journal J. Biol. Chem
Journal Reference v277 i35 p31639 (2002)