Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:998:inout-urn:agi-complex:3000112:
Entities CDC42 ---- Phosphatidylinositol 3-kinase
References 19
MedLine Reference 7629060:1014
Sentence Phosphoinositide 3-kinase also bound to Rac1 and Cdc42Hs, and these interactions were GTP-dependent.
Journal J. Biol. Chem
Journal Reference v270 i30 p17656 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/30/17656
Organism rat
Source Curated
MedLine Reference 11679587:1046
Sentence PI-3 kinase has been reported to bind to the small GTP-binding proteins Rac1 and Cdc42 ( 8 , 9 , 50 ).
CellType t cell
Journal J. Biol. Chem
Journal Reference v277 i2 p912 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/2/912
Organism mouse
Source Curated
MedLine Reference 11726672:1226
Sentence Although it has been shown that PI3K binds to Rac1 and CDC42 ( 27 ), it is not clear how PI3K regulates Rac1 and CDC42 activity and how Rac1 triggers CDC42 activation.
Journal J. Biol. Chem
Journal Reference v277 i6 p4003 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/6/4003
Source Curated
MedLine Reference 9834070:1274
CellType b cell
Journal J. Immunol
Journal Reference v161 i11 p5901 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/161/11/5901
Source Curated
MedLine Reference 10640750:1258
Journal J. Immunol
Journal Reference v164 i3 p1355 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/3/1355
Source Curated
MedLine Reference 11038173:1198
Journal J. Cell Biol
Journal Reference v151 i2 p249 (2000)
Journal Link http://www.jcb.org/cgi/content/full/151/2/249
Organism mouse
Source Curated
MedLine Reference 12566459:1243
CellType adipocyte
Journal J. Biol. Chem
Journal Reference v278 i16 p13765 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/16/13765
Organism mouse
Source Curated
CellLineName 3T3 L1
MedLine Reference 11748228:1243
Journal J. Biol. Chem
Journal Reference v277 i10 p7816 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/10/7816
Organism rat
Source Curated
CellLineName PC 12
MedLine Reference 10212202:1031
Journal J. Biol. Chem
Journal Reference v274 i18 p12323 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/18/12323
Source Curated
MedLine Reference 9115241:1034
Journal J. Biol. Chem
Journal Reference v272 i18 p11832 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/18/11832
Organism mouse
Source Curated
MedLine Reference 8955143:1235
CellType platelet
Journal J. Biol. Chem
Journal Reference v271 i51 p32986 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/51/32986
Source Curated
MedLine Reference 8702668:1130
CellType myotube
Journal J. Biol. Chem
Journal Reference v271 i33 p19664 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/33/19664
Organism rat
Source Curated
MedLine Reference 14551213:1268
Journal J. Biol. Chem
Journal Reference v278 i52 p52154 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/52/52154
Source Curated
MedLine Reference 10748040:1272
Tissue hyphae
Journal J. Biol. Chem
Journal Reference v275 i22 p16933 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/22/16933
Organism mouse
Source Curated
MedLine Reference 10411652:1326
Journal Eur. J. Biochem
Journal Reference v262 i3 p879 (1999)
Journal Link http://www.ejbiochem.org/cgi/content/full/262/3/879
Source Curated
MedLine Reference 9381982:0
Organism mouse
Source Curated
MedLine Reference 10891486:1271
Journal Mol. Cell. Biol
Journal Reference v20 i15 p5469 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/15/5469
Source Curated
CellLineName JURKAT
MedLine Reference 10594017:1036
CellType fibroblast
Journal Mol. Cell. Biol
Journal Reference v20 i1 p158 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/1/158
Organism mouse
Source Curated
MedLine Reference 2955343296
Sentence Previous studies have shown that Cdc42 can bind to the p85 regulatory subunit of PI3K in a GTP-dependent manner, and one group further suggested that this results in a weak activation of PI3K in vitro ( Zheng et al., 1994 ).
Journal Cell
Journal Reference v85 i4 p573 (1996)
Journal Link http://www.cell.com/cgi/content/full/85/4/573
Source Curated
CellLineName V12