Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-llid:7186:inout-urn:agi-llid:7132:
Entities TNFRSF1A ---- TRAF2
References 147
MedLine Reference 15115707:10
Sentence Thus delta-PKC and PI 3-kinase are positive regulators of TNF-mediated association of TRAF2 and RIP with TNFR-1.
MedLine Reference 12721308:7
Sentence In an in vitro binding assay, the intracellular domain of TNF-R1 bound TRADD, RIP, and TRAF2 but did not bind FADD or caspase-8.
CellLineName JURKAT
MedLine Reference 12963644:13
Sentence These results suggest that physiological shear stress is antiinflammatory by specifically inhibiting MAP kinase signaling and inhibiting TRAF-2 interaction with TNFR-1.
Organism Mus musculus
MedLine Reference 9927690:10025
Journal PNAS
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Journal PNAS
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MedLine Reference 9435232:10101
Journal PNAS
Journal Reference v95 i2 p565
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Organism Mus musculus
MedLine Reference 9742107:10039
MedLine Reference 9488716:10169
Journal J. Biol. Chem
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Journal Reference v26 i9 p3505
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MedLine Reference 10820260:7
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Organ kidney
CellLineName 293T
MedLine Reference 10228165:10
MedLine Reference 10795740:3
CellType fibroblast
MedLine Reference 11278289:10040
Journal J. Biol. Chem
Journal Reference v276 i16 p12749
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Organism Mus musculus
MedLine Reference 15983368:10164
Journal PNAS
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MedLine Reference 15310755:10028
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Organism Mus musculus
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Journal Heart Circul
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Organism Mus musculus
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Organism Mus musculus
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Journal PNAS
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Journal Link http://www.pnas.org/cgi/content/full/94/19/10057
MedLine Reference 10919658:10284
Journal Cancer Res
Journal Reference v60 i14 p3838
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/14/3838
Organism Mus musculus
MedLine Reference 16581782:10381
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Journal Link http://mcb.asm.org/cgi/content/full/26/8/3071
Organism Mus musculus
MedLine Reference 9724248:10054
Journal Gastr. Liver Phys
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MedLine Reference 12517920:10197
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MedLine Reference 15647289:10045
Journal J. Biol. Chem
Journal Reference v280 i12 p11395
Journal Link http://www.jbc.org/cgi/content/full/280/12/11395
Organism Mus musculus
MedLine Reference 12897154:10020
Journal Mol. Cell. Biol
Journal Reference v23 i16 p5849
Journal Link http://mcb.asm.org/cgi/content/full/23/16/5849
Organism Mus musculus
MedLine Reference 12031968:10035
Journal Diabetes
Journal Reference v51 i6 p1805
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/51/6/1805
Organism Mus musculus
MedLine Reference 9353251:10201
Journal Genes & Dev
Journal Reference v11 i21 p2810
Journal Link http://www.genesdev.org/cgi/content/full/11/21/2810
MedLine Reference 10465784:10222
Journal Genes & Dev
Journal Reference v13 i16 p2059
Journal Link http://www.genesdev.org/cgi/content/full/13/16/2059
Organism Mus musculus
MedLine Reference 16020544:10281
Journal J. Biol. Chem
Journal Reference v280 i36 p31572
Journal Link http://www.jbc.org/cgi/content/full/280/36/31572
Organism Mus musculus
MedLine Reference 12920112:10249
Journal J. Biol. Chem
Journal Reference v278 i45 p44338
Journal Link http://www.jbc.org/cgi/content/full/278/45/44338
MedLine Reference 15485837:10196
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/279/51/53266
MedLine Reference 10428814:10229
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/274/32/22414
MedLine Reference 15383523:10263
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Journal Link http://www.jbc.org/cgi/content/full/279/53/55855
MedLine Reference 11390377:10189
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/276/32/30216
MedLine Reference 14711835:10229
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/279/15/15096
MedLine Reference 12939259:10127
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/278/45/44091
Organism Mus musculus
MedLine Reference 10788437:10153
Journal J. Biol. Chem
Journal Reference v275 i18 p13307
Journal Link http://www.jbc.org/cgi/content/full/275/18/13307
MedLine Reference 15256485:10218
Journal Carcinogenesis
Journal Reference v25 i11 p2191
Journal Link http://carcin.oxfordjournals.org/cgi/content/full/25/11/2191
MedLine Reference 9104814:10241
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Journal Link http://www.jem.org/cgi/content/full/185/7/1275
MedLine Reference 15169835:10174
Journal Cell Sci
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Journal Cell
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Journal Circulation Res
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Journal Link http://circres.ahajournals.org/cgi/content/full/79/4/736
MedLine Reference 9242174:10113
Journal Circulation Res
Journal Reference v81 i2 p137
Journal Link http://circres.ahajournals.org/cgi/content/full/81/2/137
MedLine Reference 10384116:10293
Journal J. Immunol
Journal Reference v163 i1 p194
Journal Link http://www.jimmunol.org/cgi/content/full/163/1/194
Organism Mus musculus
MedLine Reference 15710601:10251
Journal J. Biol. Chem
Journal Reference v280 i17 p17203
Journal Link http://www.jbc.org/cgi/content/full/280/17/17203
MedLine Reference 15090542:10214
Journal J. Biol. Chem
Journal Reference v279 i25 p26287
Journal Link http://www.jbc.org/cgi/content/full/279/25/26287
MedLine Reference 12189195:10162
Journal Carcinogenesis
Journal Reference v23 i9 p1511
Journal Link http://carcin.oupjournals.org/cgi/content/full/23/9/1511
MedLine Reference 15743837:10238
Journal Mol. Cell. Biol
Journal Reference v25 i6 p2450
Journal Link http://mcb.asm.org/cgi/content/full/25/6/2450
MedLine Reference 9813034:10198
Organism Rattus norvegicus
MedLine Reference 9886420:10148
Journal J. Immunol
Journal Reference v162 i1 p460
Journal Link http://www.jimmunol.org/cgi/content/full/162/1/460
MedLine Reference 11877450:1026
Sentence Among members of this family, TRAF2 binds directly to TNFR2 and CD30 and indirectly to TNFR1 through TRADD and RIP.
Organ kidney
Tissue endothelial
CellType neural
Journal Mol. Pharm
Journal Reference v96 i3 p1042 (1999)
Journal Link http://www.pnas.org/cgi/content/full/96/3/1042
Organism guinea
Source Curated
CellLineName 293T
MedLine Reference 10688869:1105
Sentence TRADD recruits RIP and TNF receptor-associated factor (TRAF-2), leading to activation of nuclear factor kappaB (NF-kappaB), which suppresses TNF-alpha-induced apoptosis ( 47 ).
Journal Carcinogenesis
Journal Reference v21 i3 p485 (2000)
Journal Link http://carcin.oupjournals.org/cgi/content/full/21/3/485
Source Curated
MedLine Reference 10919658:1181
Sentence TNF-induced NF- B activation is mediated through sequential interaction of the TNF receptor with TRADD, TRAF2, NIK, and IKK-????, resulting in phosphorylation of I Ba (35, 36) .
Journal Cancer Res
Journal Reference v60 i14 p3838 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/14/3838
Organism mouse
Source Curated
CellLineName HeLa
MedLine Reference 10228165:1014
Sentence Although both LMP1 and TNFR1 interact with TRADD and TRAF2, the different topologies of the signaling complexes correlate with substantial differences between LMP1 and TNFR1 signal transduction to JNK1.
Journal EMBO
Journal Reference v18 i9 p2511 (1999)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/18/9/2511
Source Curated
MedLine Reference 12031968:1035
Sentence On the other hand, TRADD associated with TNFR1 can recruit RIP (receptor-interacting protein) ( 21 , 22 ) and TRAF2 (TNF receptor?????? associated factor 2) ( 23 ) to initiate a signaling cascade leading to the activation and translocation of NF- B to the nucleus.
Journal Diabetes
Journal Reference v51 i6 p1805 (2002)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/51/6/1805
Organism mouse
Source Curated
MedLine Reference 9242174:1112
Sentence FAF1, a novel Fas-associated protein without homology to death domain or other known proteins, interacts selectively with Fas but not a defective Fas mutation and potentiates Fas-dependent apoptosis. 91 FAP-1, a protein tyrosine phosphatase, binds the C-terminus of Fas and partially inhibits apoptosis. 92 TRAF2, a TNFR-associated factor, binds TNFR2 directly, recruiting TRAF1 to the receptor; TNFR1 binds both TRAF1 and TRAF2 indirectly, using TRADD as an adaptor protein. 93 TRADD also recruits FADD to TNFR1.
Journal Circulation Res
Journal Reference v81 i2 p137 (1997)
Journal Link http://circres.ahajournals.org/cgi/content/full/81/2/137
Source Curated
MedLine Reference 9813034:1198
Journal J. Biol. Chem
Journal Reference v273 i47 p31262 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/47/31262
Organism rat
Source Curated
MedLine Reference 9488716:1170
Journal J. Biol. Chem
Journal Reference v273 i10 p5808 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/10/5808
Source Curated
MedLine Reference 12721308:1019
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/278/28/25534
Source Curated
CellLineName JURKAT
MedLine Reference 12517920:1234
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/278/14/11858
Source Curated
MedLine Reference 11821416:1224
Journal J. Biol. Chem
Journal Reference v277 i15 p13122 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/15/13122
Source Curated
MedLine Reference 10788437:1151
Journal J. Biol. Chem
Journal Reference v275 i18 p13307 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/18/13307
Source Curated
CellLineName HeLa
MedLine Reference 10748190:1277
Journal J. Biol. Chem
Journal Reference v275 i20 p15060 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/20/15060
Source Curated
CellLineName HeLa
MedLine Reference 10428814:1228
Journal J. Biol. Chem
Journal Reference v274 i32 p22414 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/32/22414
Source Curated
CellLineName 35
MedLine Reference 9353251:1142
Journal Genes & Dev
Journal Reference v11 i21 p2810 (1997)
Journal Link http://www.genesdev.org/cgi/content/full/11/21/2810
Source Curated
CellLineName 293
MedLine Reference 12881424:1007
CellType fibroblast
Journal EMBO
Journal Reference v22 i15 p3898 (2003)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/22/15/3898
Organism mouse
Source Curated
MedLine Reference 10356400:1202
Journal EMBO
Journal Reference v18 i11 p3044 (1999)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/18/11/3044
Source Curated
CellType t cell
Journal J. Exp. Med
Journal Reference v196 i1 p15 (2002)
Journal Link http://www.jem.org/cgi/content/full/196/1/15
Source Curated
CellType t cell
Journal J. Exp. Med
Journal Reference v196 i1 p15 (2002)
Journal Link http://www.jem.org/cgi/content/full/196/1/15
Source Curated
MedLine Reference 9104814:1241
Journal J. Exp. Med
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Source Curated
MedLine Reference 10385526:1272
Journal J. Cell Biol
Journal Reference v145 i7 p1471 (1999)
Journal Link http://www.jcb.org/cgi/content/full/145/7/1471
Organism mouse
Source Curated
MedLine Reference 9582383:1012
CellType b cell
Journal J. Biol. Chem
Journal Reference v273 i21 p13353 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/21/13353
Source Curated
MedLine Reference 9488730:1009
Journal J. Biol. Chem
Journal Reference v273 i10 p5916 (1998)
Journal Link http://www.jbc.org/cgi/content/full/273/10/5916
Source Curated
CellLineName 293
MedLine Reference 9334169:1007
Journal J. Biol. Chem
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Source Curated
MedLine Reference 7592751:1009
Journal J. Biol. Chem
Journal Reference v270 i43 p25715 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/43/25715
Organism mouse
Source Curated
MedLine Reference 14519761:1207
CellType adipocyte
Journal J. Biol. Chem
Journal Reference v278 i50 p50615 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/50/50615
Source Curated
CellLineName HeLa
MedLine Reference 12591926:1024
Journal J. Biol. Chem
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Source Curated
MedLine Reference 12237315:1027
CellType osteoclast
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/277/49/47366
Organism mouse
Source Curated
MedLine Reference 11805080:1078
CellType adipocyte
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/277/11/8771
Organism mouse
Source Curated
CellLineName T3
MedLine Reference 11387332:1402
Journal J. Biol. Chem
Journal Reference v276 i34 p32080 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/34/32080
Source Curated
MedLine Reference 11112773:1013
Tissue vascular
Journal J. Biol. Chem
Journal Reference v276 i11 p8341 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/11/8341
Source Curated
MedLine Reference 10980203:1036
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/275/48/37966
Source Curated
MedLine Reference 10559258:1033
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/274/47/33684
Source Curated
MedLine Reference 15631011:1
Organism horse
Source Curated
MedLine Reference 15545599:0
CellType b cell
Organism mouse
Source Curated
MedLine Reference 11804328:4
CellType t cell
Organism yeast
Source Curated
MedLine Reference 11784851:2
Organism rat
Source Curated
MedLine Reference 10514016:0
Organism mouse
Source Curated
MedLine Reference 10074428:6
Organ kidney
Organism mouse
Source Curated
CellLineName 293
MedLine Reference 10409763:1231
Journal Mol. Cell. Biol
Journal Reference v19 i8 p5759 (1999)
Journal Link http://mcb.asm.org/cgi/content/full/19/8/5759
Source Curated
MedLine Reference 12401883:1221
Journal Lipid Res
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Source Curated
MedLine Reference 11046018:1023
Journal J. Immunol
Journal Reference v165 i9 p4927 (2000)
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Source Curated
MedLine Reference 10384146:1243
Journal J. Immunol
Journal Reference v163 i1 p434 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/1/434
Organism mouse
Source Curated
MedLine Reference 10820260:1191
Journal J. Immunol
Journal Reference v164 i11 p5815 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/164/11/5815
Source Curated
CellLineName HeLa
MedLine Reference 10384116:1293
Organ thymal
Journal J. Immunol
Journal Reference v163 i1 p194 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/1/194
Organism mouse
Source Curated
MedLine Reference 9841923:1155
Journal J. Exp. Med
Journal Reference v188 i11 p2091 (1998)
Journal Link http://www.jem.org/cgi/content/full/188/11/2091
Organism drosophila
Source Curated
CellLineName 293
MedLine Reference 9607925:1017
CellType t cell
Journal J. Exp. Med
Journal Reference v187 i11 p1849 (1998)
Journal Link http://www.jem.org/cgi/content/full/187/11/1849
Organism mouse
Source Curated
Journal J. Exp. Med
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Journal Link http://www.jem.org/cgi/content/full/196/7/923
Source Curated
Journal J. Exp. Med
Journal Reference v196 i7 p923 (2002)
Journal Link http://www.jem.org/cgi/content/full/196/7/923
Source Curated
MedLine Reference 12920112:1252
Journal J. Biol. Chem
Journal Reference v278 i45 p44338 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/45/44338
Source Curated
CellLineName HeLa
MedLine Reference 12796506:1017
Organ kidney
Journal J. Biol. Chem
Journal Reference v278 i33 p30711 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/33/30711
Source Curated
CellLineName 293T
MedLine Reference 11390377:1189
Journal J. Biol. Chem
Journal Reference v276 i32 p30216 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/32/30216
Source Curated
CellLineName HEK293t
MedLine Reference 11278289:1038
Journal J. Biol. Chem
Journal Reference v276 i16 p12749 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/16/12749
Organism mouse
Source Curated
MedLine Reference 11031256:1311
Journal J. Biol. Chem
Journal Reference v276 i2 p1195 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/2/1195
Source Curated
MedLine Reference 10465784:1040
Journal Genes & Dev
Journal Reference v13 i16 p2059 (1999)
Journal Link http://www.genesdev.org/cgi/content/full/13/16/2059
Organism drosophila
Source Curated
MedLine Reference 8831497:1272
Journal Circulation Res
Journal Reference v79 i4 p736 (1996)
Journal Link http://circres.ahajournals.org/cgi/content/full/79/4/736
Source Curated
CellLineName U 937
Journal Cell
Journal Reference v88 i3 p355 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/3/355
Source Curated
Journal Cell
Journal Reference v88 i3 p355 (1997)
Journal Link http://www.cell.com/cgi/content/full/88/3/355
Source Curated
Journal Cell
Journal Reference v84 i2 p299 (1996)
Journal Link http://www.cell.com/cgi/content/full/84/2/299
Source Curated
CellLineName 293
Journal Cell
Journal Reference v84 i2 p299 (1996)
Journal Link http://www.cell.com/cgi/content/full/84/2/299
Source Curated
CellLineName 293
MedLine Reference 12676996:1021
CellType macrophage
Journal PNAS
Journal Reference v100 i8 p4831 (1996)
Journal Link http://www.pnas.org/cgi/content/full/100/8/4831
Organism mouse
Source Curated
MedLine Reference 9435232:1103
CellType keratinocyte
Journal PNAS
Journal Reference v95 i2 p565 (1998)
Journal Link http://www.pnas.org/cgi/content/full/95/2/565
Organism mouse
Source Curated
CellLineName BALB/MK
MedLine Reference 14585990:1215
Journal Mol. Cell. Biol
Journal Reference v23 i22 p8334 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/22/8334
Organism mouse
Source Curated
CellLineName NIH 3T3
MedLine Reference 12370297:1039
Journal Mol. Cell. Biol
Journal Reference v22 i21 p7512 (2002)
Journal Link http://mcb.asm.org/cgi/content/full/22/21/7512
Organism mouse
Source Curated
MedLine Reference 10688665:1038
Journal Mol. Cell. Biol
Journal Reference v20 i6 p2198 (2000)
Journal Link http://mcb.asm.org/cgi/content/full/20/6/2198
Organism mouse
Source Curated
MedLine Reference 14585994:1
Organism mouse
Source Curated
Journal PNAS
Journal Reference v94 i19 p10057 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/19/10057
Source Curated
MedLine Reference 9927690:1025
Journal PNAS
Journal Reference v96 i3 p1042 (1999)
Journal Link http://www.pnas.org/cgi/content/full/96/3/1042
Source Curated
MedLine Reference 9294162:1033
CellType neural
Journal PNAS
Journal Reference v94 i19 p10057 (1997)
Journal Link http://www.pnas.org/cgi/content/full/94/19/10057
Source Curated
MedLine Reference 8943045:1073
Journal PNAS
Journal Reference v93 i24 p13973 (1996)
Journal Link http://www.pnas.org/cgi/content/full/93/24/13973
Source Curated
MedLine Reference 12606782:1201
Journal Mol. Pharm
Journal Reference v63 i3 p714 (2003)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/63/3/714
Organism guinea
Source Curated
MedLine Reference 12944486:1158
Journal Mol. Cell. Biol
Journal Reference v23 i18 p6609 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/18/6609
Organism mouse
Source Curated
MedLine Reference 12897154:1020
Journal Mol. Cell. Biol
Journal Reference v23 i16 p5849 (2003)
Journal Link http://mcb.asm.org/cgi/content/full/23/16/5849
Organism mouse
Source Curated
MedLine Reference 9647239:1027
Tissue endothelial
Journal J. Immunol
Journal Reference v161 i1 p319 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/161/1/319
Source Curated
MedLine Reference 9886420:1148
CellType leukocyte
Journal J. Immunol
Journal Reference v162 i1 p460 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/1/460
Source Curated
MedLine Reference 9461607:1024
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/273/7/4129
Source Curated
MedLine Reference 11801607:1031
Journal J. Biol. Chem
Journal Reference v277 i13 p10842 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/13/10842
Source Curated
MedLine Reference 11751921:1029
Journal J. Biol. Chem
Journal Reference v277 i10 p8346 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/10/8346
Organism mouse
Source Curated
MedLine Reference 12939259:1128
Tissue epithelia
Journal J. Biol. Chem
Journal Reference v278 i45 p44091 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/45/44091