Protein : MAP3K7IP1
Owner Public
URN urn:agi-llid:10454
Hugo ID 18157
Connectivity 91
Name MAP3K7IP1
Description mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Notes The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
MGI ID 1913763
Pathway Jnk-mapk
p38 MAPK
TGF-beta signaling
NF-kB Signaling
Toll-Like Receptor pathway
MAPK signaling
DDR1 -> NF-kB signaling pathway
Group activation of MAPKKK activity
catalytic activity
protein binding
protein kinase activity
enzyme activator activity
transforming growth factor beta receptor, cytoplasmic mediator activity
GenBank ID NC_000022
NM_153497
NP_705717
NM_006116
NP_006107
NT_011520
NW_927628
AC_000065
DQ314876
ABC40735
Z83845
CAB55304
AB209372
BAD92609
AF425640
AAN32760
AI827837
BC038582
BC050554
AAH50554
U49928
AAC12660
Q15750
Q59FT7
Q8IZW2
NC_000081
NM_025609
NP_079885
NT_039621
NW_000106
NW_001030577
AC_000037
AC161199
AB088136
BAC43729
AI586111
AK003343
AK009321
BAB26215
AK206012
BC027054
AAH27054
BC041110
AAH41110
BC054369
AAH54369
BC114637
AAI14638
Q8CF89
Source Curated
LocusLink ID 10454
66513
Organism Homo sapiens
Mus musculus
OMIM ID 602615
Alias TAB1
MGC57664
mitogen-activated protein kinase kinase kinase 7 interacting protein 1
TAK1-binding protein 1
transforming growth factor beta-activated kinase-binding protein 1
2310012M03Rik
beta activated kinase-1 binding protein-1
GO ID 0003824
0008047
0005515
0004672
0005072
0000185
Swiss-Prot Accession Q15750
Q59FT7
Q8IZW2
Q8CF89
Unigene ID Hs.507681
Mm.288245