Protein : TGFBR2


Owner	Public
URN	urn:agi-llid:7048
Hugo ID	11773
Connectivity	267
Name	TGFBR2
Description	transforming growth factor, beta receptor II
Notes	receptor for TGF-beta; may play a role in lung maturation and response to hypoxia [RGD]


RGD ID	69651


MGI ID	98729


Cell Localization	Plasma membrane


Pathway	TGF-beta signaling
	Wnt signaling
	p38 Signaling
	TGFR2-TGFR1
	TGFR2-ALK1
	ACVRL1/TGFBR2 -> SMAD1 signaling pathway
	ACVRL1/TGFBR2 -> SMAD5 signaling pathway
	ACVRL1/TGFBR2 -> SMAD9 signaling pathway
	TGFBR -> AP-1 signaling pathway
	TGFBR -> ATF2 signaling pathway
	TGFBR -> CREB1 signaling pathway
	TGFBR -> ELK1-SRF signaling pathway
	TGFBR -> ELK4-SRF signaling pathway
	TGFBR -> GADD153 signaling pathway
	TGFBR -> MAX signaling pathway
	TGFBR -> MEF2A signaling pathway
	TGFBR -> MEF2C signaling pathway
	TGFBR -> SMAD2/3 signaling pathway
	TGFBR -> TP53 signaling pathway


Group	Kinases
	Receptors
	transmembrane receptor protein serine-threonine kinase signaling pathway
	transforming growth factor beta receptor signaling pathway
	common-partner SMAD protein phosphorylation
	regulation of cell proliferation
	negative regulation of cell proliferation
	positive regulation of cell proliferation
	protein amino acid dephosphorylation
	protein amino acid phosphorylation
	receptor mediated endocytosis
	heart development
	response to hypoxia
	cell surface
	membrane
	cytoplasm
	cytosol
	integral to membrane
	integral to plasma membrane
	caveola
	nucleotide binding
	protein binding
	metal ion binding
	manganese ion binding
	magnesium ion binding
	ATP binding
	mitogen-activated protein kinase kinase kinase binding
	protein homodimerization activity
	protein heterodimerization activity
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity
	receptor signaling protein serine-threonine kinase activity
	transmembrane receptor protein serine-threonine kinase activity
	transforming growth factor beta receptor activity
	transforming growth factor beta receptor activity, type II
	receptor activity


Source	Curated


Alias	AAT3
	FAA3
	MFS2
	RIIC
	TAAD2
	HNPCC6
	TGFR-2
	TGFbeta-RII
	transforming growth factor, beta receptor II
	TGF-beta type II receptor
	TGF-beta receptor type IIB
	transforming growth factor beta receptor type IIC
	transforming growth factor, beta receptor II (70-80kD)
	DNIIR
	RIIDN
	AU042018
	TbetaRII
	TbetaR-II
	1110020H15Rik
	TGF-beta receptor II
	TGF-beta 2
	transforming growth factor-b type II receptor
	transforming growth factor beta receptor 2
	transforming growth factor beta, receptor 2
	transforming growth factor, beta receptor 2
	transforming growth factor-beta type II receptor