Protein : TGFBR1


Owner	Public
URN	urn:agi-llid:7046
Hugo ID	11772
Connectivity	278
Name	TGFBR1
Description	transforming growth factor, beta receptor 1
Notes	forms a heteromeric receptor complex with TGF-beta type II receptor that binds TGF-beta and mediates TGF-beta signalling [RGD]


RGD ID	3852


MGI ID	98728


Cell Localization	Plasma membrane


Pathway	TGF-beta signaling
	TGFR2-TGFR1
	TGFBR -> AP-1 signaling pathway
	TGFBR -> ATF2 signaling pathway
	TGFBR -> CREB1 signaling pathway
	TGFBR -> ELK1-SRF signaling pathway
	TGFBR -> ELK4-SRF signaling pathway
	TGFBR -> GADD153 signaling pathway
	TGFBR -> MAX signaling pathway
	TGFBR -> MEF2A signaling pathway
	TGFBR -> MEF2C signaling pathway
	TGFBR -> SMAD2/3 signaling pathway
	TGFBR -> TP53 signaling pathway


Group	Kinases
	Receptors
	cell-matrix adhesion
	signal transduction
	transmembrane receptor protein serine-threonine kinase signaling pathway
	transforming growth factor beta receptor signaling pathway
	transforming growth factor beta receptor complex assembly
	neuron fate commitment
	germ cell migration
	protein amino acid phosphorylation
	protein amino acid autophosphorylation
	collagen fibril organization
	embryonic development
	embryonic development (sensu Mammalia)
	response to estrogen stimulus
	membrane
	apical plasma membrane
	integral to membrane
	integral to plasma membrane
	basolateral plasma membrane
	extracellular space
	nucleotide binding
	protein binding
	metal ion binding
	manganese ion binding
	magnesium ion binding
	ATP binding
	transforming growth factor beta binding
	protein heterodimerization activity
	transferase activity
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein-tyrosine kinase activity
	receptor signaling protein serine-threonine kinase activity
	transmembrane receptor protein serine-threonine kinase activity
	transforming growth factor beta receptor activity
	transforming growth factor beta receptor activity, type I
	receptor activity


Source	Curated


Alias	SKR4
	ALK-5
	TGFR-1
	ACVRLK4
	transforming growth factor, beta receptor I
	activin receptor-like kinase 5
	serine/threonine-protein kinase receptor R4
	activin A receptor type II-like kinase, 53kD
	transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
	ALK5
	TbetaRI
	AU017191
	TbetaR-I
	MGC93659
	transforming growth factor, beta receptor 1
	transforming growth factor beta receptor I