Protein : MADH7


Owner	Public
URN	urn:agi-llid:4092
Hugo ID	6773
Connectivity	492
Name	MADH7
Description	MAD homolog 7 (Drosophila)
Notes	negative regulator of TGF-beta and activin [RGD]


RGD ID	69314


MGI ID	1100518


Cell Localization	Nucleus


Pathway	TGF-beta signaling
	ACVR1B/2A -> SMAD2/3 signaling pathway
	ACVR1B/2B -> SMAD2/3 signaling pathway
	ACVR1C/2A -> SMAD2/3 signaling pathway
	ACVR1C/2B -> SMAD2/3 signaling pathway
	ACVR1C/BMPR2 -> SMAD2/3 signaling pathway
	TGFBR -> SMAD2/3 signaling pathway


Group	Transcription factors
	intracellular signaling cascade
	transforming growth factor beta receptor signaling pathway
	common-partner SMAD protein phosphorylation
	regulation of transforming growth factor beta receptor signaling pathway
	transcription
	negative regulation of transcription
	regulation of transcription, DNA-dependent
	response to stress
	cellular_component
	intracellular
	nucleus
	protein binding
	receptor signaling protein serine-threonine kinase signaling protein activity
	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity


GenBank ID	NC_000018
	NM_005904
	NP_005895
	NT_010966
	NW_927106
	AC_000061
	AC114684
	AF026559
	AAL68977
	AF156731
	AF010193
	AAB81246
	AF015261
	AAB81354
	AK131394
	BC074818
	AAH74818
	BC074819
	AAH74819
	O15105
	NC_000084
	NM_008543
	NP_032569
	NT_039674
	NW_000134
	NW_001030635
	XM_986975
	XP_992069
	AC_000040
	NM_001042660
	NP_001036125
	AC120156
	AF167314
	AB221688
	AF015260
	AAB81353
	AJ000550
	CAA04182
	AJ000551
	CAA04183
	AK013237
	AK133505
	O35253
	NC_005117
	NM_030858
	NP_110485
	NW_001084737
	XM_001054518
	XP_001054518
	NW_047516
	AC_000086
	AF156727
	AAF00608
	AF156728
	AF156729
	AF156730
	AF042499
	AAC25062
	AF159626
	AAD41130
	O88406


Source	Curated


LocusLink ID	4092
	17131
	81516


Organism	Homo sapiens
	Mus musculus
	Rattus norvegicus


OMIM ID	602932


Alias	MADH7
	MADH8
	FLJ16482
	MAD, mothers against decapentaplegic homolog 7
	Mothers against decapentaplegic, drosophila, homolog of, 7
	MAD (mothers against decapentaplegic, Drosophila) homolog 7
	MAD, mothers against decapentaplegic homolog 7 (Drosophila)
	MAD homolog 7
	Smad7
	MAD (mothers against decapentaplegic Drosophila) homolog 7


GO ID	0005515
	0005076
	0030617
	0006355
	0006950
	0006350
	0007179
	0005622
	0005634
	0007182
	0008372
	0007242
	0016481
	0017015


Swiss-Prot Accession	O15105
	O35253
	O88406


Unigene ID	Hs.465087
	Mm.34407
	Rn.29980