Protein : cytosol SMAD4
Owner Public
URN urn:agi-llid:4089
Hugo ID 6770
Connectivity 685
Name cytosol SMAD4
Description MAD homolog 4 (Drosophila)
Notes transduces signal from TGF-beta; deletion of human homolog gene is associated with pancreatic carcinomas [RGD]
RGD ID 3033
MGI ID 894293
Cell Localization Nucleus
Pathway Jnk-mapk
BMPR2-BMPR1A
TGF-beta signaling
BMPR2-AcvR1
AMHR-BMPR1A
AMHR-AcvR1
AcvR2B-BMPR1B
AcvR2B-BMPR1A
AcvR2B-ALK7
TGFR2-TGFR1
SAPK-JNK Signaling
AcvR2B-AcvR1B
TGFR2-ALK1
AcvR2B-AcvR1
BMPR2-BMPR1B
AcvR2-AcvR1
AMHR-BMPR1B
ACVR1/2A -> SMAD1 signaling pathway
BMPR1A/2 -> SMAD1 signaling pathway
BMPR1A/2 -> SMAD5 signaling pathway
BMPR1A/2 -> SMAD9 signaling pathway
BMPR1A/ACVR2A -> SMAD1 signaling pathway
BMPR1A/ACVR2A -> SMAD5 signaling pathway
BMPR1A/ACVR2A -> SMAD9 signaling pathway
ACVR1/2A -> SMAD5 signaling pathway
BMPR1A/ACVR2B -> SMAD1 signaling pathway
BMPR1A/ACVR2B -> SMAD5 signaling pathway
BMPR1A/ACVR2B -> SMAD9 signaling pathway
BMPR1B/2 -> SMAD1 signaling pathway
ACVR1/2A -> SMAD9 signaling pathway
BMPR1B/2 -> SMAD5 signaling pathway
BMPR1B/2 -> SMAD9 signaling pathway
BMPR1B/ACVR2A -> SMAD1 signaling pathway
ACVR1/2B -> SMAD1 signaling pathway
BMPR1B/ACVR2A -> SMAD5 signaling pathway
BMPR1B/ACVR2A -> SMAD9 signaling pathway
BMPR1B/ACVR2B -> SMAD1 signaling pathway
BMPR1B/ACVR2B -> SMAD5 signaling pathway
BMPR1B/ACVR2B -> SMAD9 signaling pathway
ACVR1/2B -> SMAD5 signaling pathway
ACVR1/2B -> SMAD9 signaling pathway
ACVR1/BMPR2 -> SMAD1 signaling pathway
ACVR1/BMPR2 -> SMAD5 signaling pathway
ACVR1/BMPR2 -> SMAD9 signaling pathway
ACVR1B/2A -> SMAD2/3 signaling pathway
ACVR1B/2B -> SMAD2/3 signaling pathway
ACVR1C/2A -> SMAD2/3 signaling pathway
ACVR1C/2B -> SMAD2/3 signaling pathway
ACVR1C/BMPR2 -> SMAD2/3 signaling pathway
ACVRL1/TGFBR2 -> SMAD1 signaling pathway
ACVRL1/TGFBR2 -> SMAD5 signaling pathway
ACVRL1/TGFBR2 -> SMAD9 signaling pathway
TGFBR -> SMAD2/3 signaling pathway
Group Transcription factors
common-partner SMAD protein phosphorylation
SMAD protein heteromerization
SMAD protein nuclear translocation
negative regulation of cell proliferation
transcription
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
regulation of transcription from RNA polymerase II promoter
organ morphogenesis
ureteric bud branching
gastrulation (sensu Mammalia)
anterior-posterior pattern formation
regulation of binding
intracellular
cytoplasm
nucleus
transcription factor complex
protein binding
DNA binding
transcription factor activity
transcription cofactor activity
transcriptional activator activity
GenBank ID NC_000018
NM_005359
NP_005350
NT_010966
NW_927106
AC_000061
AB043547
BAB40977
AC091551
AF045447
AAC03051
BC002379
AAH02379
BX647129
U44378
AAA91041
Q13485
Q9BYG6
NC_000084
NM_008540
NP_032566
NT_039674
NW_000134
XM_001001701
XP_001001701
XM_001001655
XP_001001655
XM_001001692
XP_001001692
XM_001001679
XP_001001679
XM_001001668
XP_001001668
XM_001001632
XP_001001632
XM_001001642
XP_001001642
NW_001030635
XM_987970
XP_993064
XM_987848
XP_992942
XM_987755
XP_992849
XM_987790
XP_992884
AC_000040
AC132418
AC134447
AY119788
AAM74472
AB221585
AI427147
AK004804
BAB23576
AK170255
AY493561
AAR85497
BC046584
AAH46584
BG073878
BG076431
BG086595
U79748
AAB57905
P97471
NC_005117
NM_019275
NP_062148
NW_001084736
NW_047516
AC_000086
AB010954
BAA83092
AF056002
AAC12781
O70437
Source Curated
LocusLink ID 4089
17128
50554
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600993
175050
174900
Alias JIP
DPC4
MADH4
mothers against decapentaplegic homolog 4
deleted in pancreatic carcinoma locus 4
Mothers against decapentaplegic, Drosophila, homolog of, 4
MAD (mothers against decapentaplegic, Drosophila) homolog 4
MAD, mothers against decapentaplegic homolog 4 (Drosophila)
D18Wsu70e
MAD homolog 4
Smad 4
MAD (mothers against decapentaplegic Drosophila) homolog 4
GO ID 0005515
0003712
0003700
0007183
0006355
0006350
0005737
0005622
0005634
0003677
0016563
0007184
0009952
0007182
0010003
0008285
0009887
0045944
0045893
0051098
0006357
0001658
0005667
Swiss-Prot Accession Q13485
Q9BYG6
P97471
O70437
Unigene ID Hs.75862
Mm.100399
Rn.9774