Protein : MADH2


Owner	Public
URN	urn:agi-llid:4087
Hugo ID	6768
Connectivity	660
Name	MADH2
Description	MAD homolog 2 (Drosophila)
Notes	transcriptional mediator for both activin and TGFbeta [RGD]


RGD ID	3031


MGI ID	108051


Cell Localization	Nucleus


Pathway	TGF-beta signaling
	AcvR2B-ALK7
	TGFR2-TGFR1
	AcvR2B-AcvR1B
	AcvR2B-AcvR1
	AcvR2-AcvR1B
	AcvR2-AcvR1
	ACVR1B/2A -> SMAD2/3 signaling pathway
	ACVR1B/2B -> SMAD2/3 signaling pathway
	ACVR1C/2A -> SMAD2/3 signaling pathway
	ACVR1C/2B -> SMAD2/3 signaling pathway
	ACVR1C/BMPR2 -> SMAD2/3 signaling pathway
	TGFBR -> SMAD2/3 signaling pathway


Group	Transcription factors
	intracellular signaling cascade
	transforming growth factor beta receptor signaling pathway
	common-partner SMAD protein phosphorylation
	SMAD protein heteromerization
	cell fate commitment
	transcription
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	mesoderm formation
	paraxial mesoderm morphogenesis
	anterior-posterior pattern formation
	regulation of binding
	intracellular
	nucleus
	transcription factor complex
	protein binding
	double-stranded DNA binding
	transcription factor binding
	transcriptional activator activity


Source	Curated


OMIM ID	601366


Alias	JV18
	MADH2
	MADR2
	JV18-1
	hMAD-2
	hSMAD2
	MGC22139
	MGC34440
	Sma- and Mad-related protein 2
	Mad protein homolog
	Mad-related protein 2
	mother against DPP homolog 2
	Mad, mothers against decapentaplegic homolog 2 (Drosophila)
	MAD homolog 2
	Smad 2
	MAD (mothers against decapentaplegic Drosophila) homolog 2