Protein : SMAD3


Owner	Public
URN	urn:agi-llid:4088
Hugo ID	6769
Connectivity	946
Name	SMAD3
Description	MAD homolog 3 (Drosophila)
Notes	transcription factor; important component of the TGF-beta signaling pathway [RGD]


RGD ID	3032


MGI ID	1201674


Cell Localization	Nucleus


Pathway	TGF-beta signaling
	AcvR2B-ALK7
	TGFR2-TGFR1
	AcvR2B-AcvR1B
	AcvR2B-AcvR1
	AcvR2-AcvR1
	NOTCH1 -> SMAD3 signaling pathway
	NTRK1 -> SMAD3 signaling pathway
	ACVR1B/2A -> SMAD2/3 signaling pathway
	ACVR1B/2B -> SMAD2/3 signaling pathway
	ACVR1C/2A -> SMAD2/3 signaling pathway
	ACVR1C/2B -> SMAD2/3 signaling pathway
	ACVR1C/BMPR2 -> SMAD2/3 signaling pathway
	TGFBR -> SMAD2/3 signaling pathway


Group	Transcription factors
	transforming growth factor beta receptor signaling pathway
	common-partner SMAD protein phosphorylation
	regulation of transforming growth factor beta receptor signaling pathway
	SMAD protein heteromerization
	regulation of epithelial cell proliferation
	transcription
	negative regulation of transcription from RNA polymerase II promoter
	positive regulation of transcription
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	organ morphogenesis
	mesoderm formation
	regulation of striated muscle development
	paraxial mesoderm morphogenesis
	regulation of binding
	intracellular
	nucleus
	plasma membrane
	protein binding
	transcription factor activity
	double-stranded DNA binding
	transcription factor binding
	transcriptional activator activity


Source	Curated


OMIM ID	603109


Alias	MADH3
	JV15-2
	Smad 3
	HSPC193
	HsT17436
	MGC60396
	DKFZP586N0721
	DKFZp686J10186
	mothers against decapentaplegic homolog 3
	mad homolog JV15-2
	mad protein homolog
	SMA- and MAD-related protein 3
	MAD, mothers against decapentaplegic homolog 3
	MAD, mothers against decapentaplegic homolog 3 (Drosophila)
	AU022421
	MAD homolog 3
	MAD (mothers against decapentaplegic Drosophila) homolog 3
	MAD (mothers against decapentaplegic, Drosophila) homolog 3