DirectRegulation :


Owner	Public
URN	urn:agi-DirectRegulation:inout-urn:agi-llid:6498:out-urn:agi-llid:4088::negative
Entities	SKIL ---\| SMAD3
References	8
Effect	negative
Connectivity	2


Sentence	These results indicate that the SnoN protein acts as a direct antagonist of Smad3 transcriptional activation.
Journal	PNAS
Source	Curated
Journal Reference	v96 i22 p12442 (1999)
Journal Link	http://www.pnas.org/cgi/content/full/96/22/12442
MedLine Reference	10535941:1122


Sentence	In tissue culture cells, SnoN degradation requires an intact destruction box and the interaction between Smad3 and SnoN (Stroschein et al. 2001 ).
Journal	Genes & Dev
Source	Curated
Journal Reference	v16 i17 p2179 (2002)
Journal Link	http://www.genesdev.org/cgi/content/full/16/17/2179
Organism	yeast
MedLine Reference	12208841:1688


Sentence	This is corroborated by the recent structural analysis of Ski interaction with Smad4, suggesting that Ski/SnoN blocks the interaction between Smad4 and the effector-Smads 2 and 3 (42) .
Journal	Cancer Res
Source	Curated
Journal Reference	v63 i16 p5005 (2003)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/63/16/5005
MedLine Reference	12941827:1148


Sentence	In TGF-eta-responsive Ba/F3 cells, TGF-eta also induced the formation of an endogenous Smad3/SnoN/APC complex (Fig. 6 D), again supporting the model that TGF-eta stimulation results in the recruitment of the APC to SnoN by Smad3.
CellLineName	Ba/F3
Journal	Heart Circul
Source	Curated
Journal Reference	v279 i2 pH520 (2000)
Journal Link	http://ajpheart.physiology.org/cgi/content/full/279/2/H520
Organism	dog
MedLine Reference	10924049:1213


Sentence	The UbcH5 family of E2 ubiquitin conjugating enzymes may be required for Smad3-induced SnoN degradation To identify the cellular machinery responsible for SnoN ubiquitination and degradation, various dominant-negative E2 ubiquitin conjugating enzymes were tested for their ability to block Smad3-induced degradation of SnoN in pulse-chase assays.
CellLineName	Hep 3B
Journal	Genes & Dev
Source	Curated
Journal Reference	v15 i21 p2822 (2001)
Journal Link	http://www.genesdev.org/cgi/content/full/15/21/2822
MedLine Reference	11691834:1149


Journal	Mol. Biol. Cell
Source	Curated
Journal Reference	v15 i3 p963 (2004)
Journal Link	http://www.molbiolcell.org/cgi/content/full/15/3/963
Organism	frog
MedLine Reference	14699069:1387


Journal	J. Biol. Chem
Source	Curated
Journal Reference	v278 i1 p531 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/1/531
MedLine Reference	12426322:1000


Journal	J. Biol. Chem
Source	Curated
Journal Reference	v277 i32 p28483 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/32/28483
Organism	mouse
Organ	liver
MedLine Reference	12023281:1183