ProtModification :

Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:5595:out-urn:agi-go:0004708::unknown
Entities MAPK3 ---> ERK activator kinase
References 13
Connectivity 2
Effect unknown
MedLine Reference 9169479:1256
Sentence Moreover, ERK1 phosphorylates MAP kinase kinase, and this phosphorylation appears to reduce MAP kinase kinase activity ( 58 ).
Journal J. Biol. Chem
Journal Reference v272 i23 p15028 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/23/15028
Organism rat
Source Curated
MedLine Reference 9637499:1188
Sentence In contrast to this, IL-16 is not able to activate the extracellular signal-regulated kinases ERK-1 and ERK-2 (Fig. 7 ).
Journal J. Immunol
Journal Reference v160 i12 p5874 (1998)
Journal Link http://www.jimmunol.org/cgi/content/full/160/12/5874
Source Curated
CellType macrophage
MedLine Reference 11872675:1018
Sentence These cells also showed an enhanced activation of mitogen-activated protein kinase (MAPK) kinase (MEK1/2) and p42/p44 mitogen-activated protein kinase (MAPK) upon insulin stimulation.
Journal Diabetes
Journal Reference v51 i3 p743 (2002)
Journal Link http://diabetes.diabetesjournals.org/cgi/content/full/51/3/743
Organism mouse
Source Curated
CellType adipocyte
MedLine Reference 9252360:1029
Sentence ERK1 and ERK2 are regulated by mitogens and growth factors via a Ras-dependent pathway involving sequential activation of a MAP kinase kinase kinase and a MAP kinase kinase (MEK) ( 4 ).
Journal J. Biol. Chem
Journal Reference v272 i33 p20490 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/33/20490
CellLineName Rat1
Organism rat
Source Curated
CellType fibroblast
MedLine Reference 11279262:1129
Sentence GGF induced a robust activation of both PI 3-kinase and MAPK kinase in the Schwann cells, as evidenced by the increased phosphorylation of Akt and MAP kinase p44/p42, respectively, detected by Western blot analysis (Fig. 1 C ).
Journal J. Neurochem
Journal Reference v77 i1 p63 (2001)
Journal Link http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc
Organism rat
Source Curated
CellType schwann
MedLine Reference 12391266:1215
Journal Mol. Pharm
Journal Reference v62 i5 p1043 (2002)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/62/5/1043
Organism rat
Source Curated
CellType neural
MedLine Reference 12469196:1
CellLineName BCE
Organism bovine
Source Curated
MedLine Reference 12909622:1205
Journal J. Biol. Chem
Journal Reference v278 i44 p42877 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/44/42877
CellLineName PC 12
Organism rat
Source Curated
MedLine Reference 12826679:1294
Journal J. Biol. Chem
Journal Reference v278 i39 p37637 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/39/37637
Source Curated
MedLine Reference 11901151:1198
Journal J. Biol. Chem
Journal Reference v277 i21 p18649 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/21/18649
CellLineName 184B5
Source Curated
MedLine Reference 10809726:1169
Journal J. Biol. Chem
Journal Reference v275 i20 p14838 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/20/14838
Source Curated
MedLine Reference 11350732:1182
Journal Cell Phys
Journal Reference v280 i6 pC1375 (2001)
Journal Link http://ajpcell.physiology.org/cgi/content/full/280/6/C1375
Tissue endothelial
Source Curated
MedLine Reference 15052200:1
Organism pig
Tissue endothelial
Organ brain
Source Curated
CellType neural