ProtModification :


Mechanism	phosphorylation
Owner	Public
URN	urn:agi-ProtModification:inout-urn:agi-go:0004708:out-urn:agi-llid:5595::unknown
Entities	ERK activator kinase ---> MAPK3
References	3
Connectivity	2
Effect	unknown


MedLine Reference	8393135:1
Sentence	A MAP kinase kinase (MKK1 or MEK1) has been identified as a dual-specificity protein kinase that is sufficient to phosphorylate MAP kinases p42mapk and p44mapk on the regulatory threonine and tyrosine residues.
Organism	rat
Source	Curated


MedLine Reference	9792705:1144
Sentence	MAPK kinase activates and phosphorylates p44/42 MAPK, but not the c-Jun N-terminal kinase/stress-activated protein kinase or p38/HOG MAPKs ( 34 ).
Journal	J. Biol. Chem
Journal Reference	v273 i45 p29879 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/45/29879
CellLineName	293T
Source	Curated


MedLine Reference	10415066:1030
Sentence	MAPK kinases or ERK kinases (MEKs) are dual specificity kinases that can phosphorylate ERK1 and ERK2 on tyrosine and threonine residues, thereby inducing ERK activity ( 23 , 24 ).
Journal	J. Immunol
Journal Reference	v163 i3 p1611 (1999)
Journal Link	http://www.jimmunol.org/cgi/content/full/163/3/1611
Tissue	endothelial
Source	Curated
CellType	leukocyte