Regulation :

Effect negative
Mechanism phosphorylation
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:4092:out-urn:agi-llid:4087::negative:phosphorylation
Entities MADH7 ---| MADH2
References 55
Connectivity 2
MedLine Reference 16902401:0
Sentence Smad7 is a molecule that blocks the Smad2/3 signal.
Organism Mus musculus
MedLine Reference 11786959:5
Sentence Thereafter, Smad 7 induced by TGF-beta negatively regulated the Smad 2 action.
Organ liver
Organism Rattus norvegicus
CellLineName HSCs
MedLine Reference 10781941:0
Sentence Smad7 was recently shown to antagonize TGF-beta-induced activation of signal-transducing Smad2 and Smad3 proteins.
Organism Mus musculus
MedLine Reference 10728705:10189
Journal Cancer Res
Journal Reference v60 i5 p1394
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/5/1394
MedLine Reference 15811853:10149
Journal J. Biol. Chem
Journal Reference v280 i23 p21858
Journal Link http://www.jbc.org/cgi/content/full/280/23/21858
MedLine Reference 15308665:10185
Journal J. Biol. Chem
Journal Reference v279 i43 p45076
Journal Link http://www.jbc.org/cgi/content/full/279/43/45076
MedLine Reference 15579469:10029
Journal J. Biol. Chem
Journal Reference v280 i9 p8079
Journal Link http://www.jbc.org/cgi/content/full/280/9/8079
MedLine Reference 14732719:10236
Journal J. Biol. Chem
Journal Reference v279 i15 p15167
Journal Link http://www.jbc.org/cgi/content/full/279/15/15167
Organism Mus musculus
MedLine Reference 11557747:10039
Journal J. Biol. Chem
Journal Reference v276 i47 p44163
Journal Link http://www.jbc.org/cgi/content/full/276/47/44163
Organism Mus musculus
MedLine Reference 16007121:3
Organism Mus musculus
MedLine Reference 10224135:5
Organism Mus musculus
CellLineName HS-72
MedLine Reference 10973944:2
MedLine Reference 10915727:7
MedLine Reference 9215638:4
MedLine Reference 11320083:8
Tissue epithelia
Organ lung
MedLine Reference 11478938:7
Organism Rattus norvegicus
CellType myofibroblast
MedLine Reference 10995749:10188
Journal J. Biol. Chem
Journal Reference v275 i49 p38363
Journal Link http://www.jbc.org/cgi/content/full/275/49/38363
MedLine Reference 10801843:10137
Journal J. Biol. Chem
Journal Reference v275 i31 p23992
Journal Link http://www.jbc.org/cgi/content/full/275/31/23992
Organism Mus musculus
MedLine Reference 14739161:10204
Journal Circulation Res
Journal Reference v94 i5 p617
Journal Link http://circres.ahajournals.org/cgi/content/full/94/5/617
MedLine Reference 11160820:10028
Journal Mol. Biol. Cell
Journal Reference v12 i1 p27
Journal Link http://www.molbiolcell.org/cgi/content/full/12/1/27
Organism Mus musculus
MedLine Reference 10085121:10280
Journal J. Biol. Chem
Journal Reference v274 i13 p8797
Journal Link http://www.jbc.org/cgi/content/full/274/13/8797
MedLine Reference 16055706:10027
Journal Mol. Cell. Biol
Journal Reference v25 i16 p6921
Journal Link http://mcb.asm.org/cgi/content/full/25/16/6921
MedLine Reference 11134049:10034
Journal J. Biol. Chem
Journal Reference v276 i14 p11041
Journal Link http://www.jbc.org/cgi/content/full/276/14/11041
MedLine Reference 11815670:10196
Journal EBM
Journal Reference v227 i2 p75
Journal Link http://www.ebmonline.org/cgi/content/full/227/2/75
MedLine Reference 16170025:10221
Journal Mol. Cancer Ther
Journal Reference v4 i9 p1338
Journal Link http://mct.aacrjournals.org/cgi/content/full/4/9/1338
MedLine Reference 11481479:10133
Journal PNAS
Journal Reference v98 i16 p9139
Journal Link http://www.pnas.org/cgi/content/full/98/16/9139
Organism Mus musculus
MedLine Reference 11443124:10021
Journal J. Biol. Chem
Journal Reference v276 i35 p32854
Journal Link http://www.jbc.org/cgi/content/full/276/35/32854
MedLine Reference 15059906:10023
Journal Cancer Res
Journal Reference v64 i7 p2509
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/64/7/2509
MedLine Reference 9334330:10247
Journal Genes & Dev
Journal Reference v11 i20 p2679
Journal Link http://www.genesdev.org/cgi/content/full/11/20/2679
MedLine Reference 11152674:10168
Journal J. Biol. Chem
Journal Reference v276 i14 p10700
Journal Link http://www.jbc.org/cgi/content/full/276/14/10700
Organism Mus musculus
MedLine Reference 11707452:10038
Journal J. Biol. Chem
Journal Reference v277 i2 p1240
Journal Link http://www.jbc.org/cgi/content/full/277/2/1240
MedLine Reference 15657037:10179
Journal J. Biol. Chem
Journal Reference v280 i11 p10870
Journal Link http://www.jbc.org/cgi/content/full/280/11/10870
Organism Mus musculus
MedLine Reference 101000737:11149
Journal Cell
Journal Reference v89 i7 p1165
Journal Link http://www.cell.com/cgi/content/full/89/7/1165
MedLine Reference 14684851:10188
Journal Mol. Endocrin
Journal Reference v18 i3 p696
Journal Link http://mend.endojournals.org/cgi/content/full/18/3/696
MedLine Reference 9716398:10242
Journal Genes & Dev
Journal Reference v12 i16 p2445
Journal Link http://www.genesdev.org/cgi/content/full/12/16/2445
MedLine Reference 10728705:1190
Sentence Smad 6 and Smad 7 inhibited the endogenous TGF-????-induced phosphorylation of Smad 2 (Fig. 7 B ) .
Journal Cancer Res
Journal Reference v60 i5 p1394 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/5/1394
Source Curated
CellLineName Mv1Lu
MedLine Reference 11815670:1199
Sentence It has been demonstrated that Smad7, but not Smad6, inhibits activin-mediated Smad2 activation in B cell hybridoma HS-72 cells ( 114 ).
Journal EBM
Journal Reference v227 i2 p75 (2002)
Journal Link http://www.ebmonline.org/cgi/content/full/227/2/75
Source Curated
CellType b cell
CellLineName HS-72
Tissue egg
Organ wing
Source Curated
MedLine Reference 11707452:1038
Journal J. Biol. Chem
Journal Reference v277 i2 p1240 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/2/1240
Organ prostate
Source Curated
MedLine Reference 11557747:1037
Journal J. Biol. Chem
Journal Reference v276 i47 p44163 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/47/44163
Organism mouse
Source Curated
MedLine Reference 11443124:1021
Journal J. Biol. Chem
Journal Reference v276 i35 p32854 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/35/32854
Source Curated
MedLine Reference 11320083:1021
Tissue epithelia
Journal J. Biol. Chem
Journal Reference v276 i28 p26349 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/26349
Organ lung
Source Curated
MedLine Reference 11152674:1172
Journal J. Biol. Chem
Journal Reference v276 i14 p10700 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/14/10700
Organism mouse
Source Curated
CellType osteoblast
MedLine Reference 10995749:1188
Journal J. Biol. Chem
Journal Reference v275 i49 p38363 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/49/38363
Source Curated
MedLine Reference 10973944:1016
Journal J. Biol. Chem
Journal Reference v275 i43 p33205 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/43/33205
Source Curated
MedLine Reference 10224135:1013
Journal J. Biol. Chem
Journal Reference v274 i19 p13637 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/19/13637
Organism mouse
Source Curated
CellLineName HS-72
MedLine Reference 10085121:1281
Tissue endothelial
Journal J. Biol. Chem
Journal Reference v274 i13 p8797 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/13/8797
Organism bovine
Source Curated
MedLine Reference 15716330:6
Tissue tubule
Organism mouse
Source Curated
CellLineName NRK52E
MedLine Reference 11134049:1034
Journal J. Biol. Chem
Journal Reference v276 i14 p11041 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/14/11041
Source Curated
MedLine Reference 10801843:1137
Tissue pulmonary
Journal J. Biol. Chem
Journal Reference v275 i31 p23992 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/31/23992
Organ lung
Organism mouse
Source Curated
Tissue endothelial
Journal Cell
Journal Reference v89 i7 p1165 (1997)
Journal Link http://www.cell.com/cgi/content/full/89/7/1165
Source Curated
MedLine Reference 11481479:1134
Journal PNAS
Journal Reference v98 i16 p9139 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/16/9139
Organism mouse
Source Curated
CellType keratinocyte
CellLineName DT
MedLine Reference 11226255:1174
Journal PNAS
Journal Reference v98 i5 p2425 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/5/2425
Organism mouse
Source Curated
MedLine Reference 11160820:1028
Tissue epithelia
Journal Mol. Biol. Cell
Journal Reference v12 i1 p27 (2001)
Journal Link http://www.molbiolcell.org/cgi/content/full/12/1/27
Organism mouse
Source Curated
MedLine Reference 3810053825
Sentence Smad7 prevents TGF?-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.
Tissue vascular
Journal Cell
Journal Reference v89 i7 p1165 (1997)
Journal Link http://www.cell.com/cgi/content/full/89/7/1165
Source Curated