Protein : ELK1
Owner Public
URN urn:agi-llid:2002
Hugo ID 3321
Connectivity 21
Name ELK1
Description ELK1, member of ETS oncogene family
Notes This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade.
RGD ID 2549
MGI ID 101833
Cell Localization Nucleus
Pathway Jnk-mapk
p38 MAPK
p40 MAPK
Insulin pathway
EGF signaling
p38 Signaling
PDGF signaling
MAPK-ERK in Growth and Differentiation
Erythropoietin signaling
IL-6 signaling
SAPK-JNK Signaling
Toll-Like Receptor pathway
IL-2 signaling
NGF signaling
MAPK signaling
AGTR1 -> ELK1-SRF signaling pathway
Notch -> ELK1-SRF signaling pathway
EDG3/5 -> ELK1-SRF signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
NTRKs -> ELK1-SRF signaling pathway
IGF1R -> ELK1-SRF signaling pathway
OPRs -> ELK1-SRF signaling pathway
PLAUR -> ELK1-SRF signaling pathway
ENDRB -> ELK1-SRF signaling pathway
F2R -> ELK1-SRF signaling pathway
PTAFR -> ELK1-SRF signaling pathway
EPOR -> ELK1-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
EPOR -> FOS signaling pathway
PTGFR -> ELK1-SRF signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
CCKAR -> ELK1-SRF signaling pathway
CCKBR -> ELK1-SRF signaling pathway
PTGIR -> ELK1-SRF signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL4R -> ELK1-SRF signaling pathway
CD19 -> ELK1-SRF signaling pathway
TACR1 -> ELK1-SRF signaling pathway
IL6R -> ELK1-SRF signaling pathway
INSR -> ELK1-SRF signaling pathway
TGFBR -> ELK1-SRF signaling pathway
FSHR -> ELK1-SRF signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
CD38 -> ELK1-SRF signaling pathway
GCGR -> ELK1-SRF signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
KDR -> ELK1-SRF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
LEPR -> ELK1-SRF signaling pathway
CNRs -> ELK1-SRF signaling pathway
GNRHR -> ELK1-SRF signaling pathway
HTR2A -> ELK1-SRF signaling pathway
TNFRs -> ELK1-SRF signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
DRD1 -> ELK1-SRF signaling pathway
ICAM1 -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
NGFR -> ELK1-SRF signaling pathway
DRD2 -> ELK1-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
Group Transcription factors
cellular physiological process
regulation of progression through cell cycle
negative regulation of apoptosis
transcription
positive regulation of transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
intracellular
nucleus
integral to membrane
potassium ion binding
DNA binding
sequence-specific DNA binding
transcription factor activity
RNA polymerase II transcription factor activity, enhancer binding
transcriptional activator activity
voltage-gated potassium channel activity
GenBank ID NC_000023
NM_005229
NP_005220
NT_079573
NW_927702
AC_000066
AB016194
BAA36617
AF080615
AF080616
AAC82466
AL009172
CAA15659
AB016193
BAA36616
AF000672
AAD00862
AK093966
BAC04259
BC048296
AAH48296
BC056150
AAH56150
CR542252
CAG47048
CR598341
M25269
AAA52384
P19419
Q59GR2
Q6FG56
Q86SR6
Q8N9S0
AB209047
BAD92284
NC_000086
NM_007922
NP_031948
NT_039700
NW_001035163
NW_042619
AC_000042
AL671853
AI385733
AK082260
AK132354
BAE21121
BC005706
BC054474
AAH54474
X87257
CAA60715
Z36939
CAA85391
P41969
NC_005120
XM_001078496
XP_001078496
NW_001091912
XM_001055949
XP_001055949
NW_048034
AC_000089
BG377323
CB547039
Source Curated
LocusLink ID 2002
13712
314436
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 311040
Alias ELK1 protein
Elk-1
ELK1, member of ETS oncogene family
GO ID 0043565
0003700
0045944
0006355
0006350
0005634
0003677
0016563
0050875
0045941
0000074
0005622
0003705
0030955
0005249
0043066
0016021
Swiss-Prot Accession P19419
Q59GR2
Q6FG56
Q86SR6
Q8N9S0
P41969
Unigene ID Hs.181128
Mm.347420
Rn.1714