ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:4214:out-urn:agi-go:0004708::positive
Entities MAP3K1 --+> ERK activator kinase
References 28
Connectivity 2
Effect positive
MedLine Reference 11574474:1228
Sentence D-MEKK1 was found to phosphorylate mammalian MAPKK MKK6, similar to its human homolog.
Journal EMBO
Journal Reference v20 i19 p5421 (2001)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/20/19/5421
Organism drosophila
Source Curated
MedLine Reference 14764730:1263
Sentence Each MAPKK, in turn, is activated by MAPKK/MEK kinase (MAPKKK or MEKK) ( 18 , 26 ).
Journal J. Immunol
Journal Reference v172 i4 p2569 (2004)
Journal Link http://www.jimmunol.org/cgi/content/full/172/4/2569
Organism Rattus norvegicus
Tissue pulmonary
Organ lung
Source Curated
MedLine Reference 7759532:1012
Sentence The activated MEKK phosphorylated not only MAPKKs but also XMEK2, which is distantly related to MAPKK.
Journal J. Biol. Chem
Journal Reference v270 i21 p12781 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/21/12781
CellLineName PC 12
Organism Rattus norvegicus
Source Curated
MedLine Reference 9606192:1052
Sentence MAPKs are activated by a MAPK kinase (MAPKK or MEK), which in turn is activated by a MAPKK or MEK kinase (MAPKKK or MEKK).
Journal EMBO
Journal Reference v17 i11 p3101 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/11/3101
Source Curated
CellType t cell
MedLine Reference 12839996:1037
Sentence MEKK1 is a MAPK kinase kinase that is activated in response to changes in cell shape and the microtubule cytoskeleton ( Yujiri et al ., 1999 ).
Journal EMBO
Journal Reference v22 i13 p3346 (2003)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/22/13/3346
Organism mouse
Source Curated
CellType fibroblast
MedLine Reference 9808624:1328
Sentence The kinetics of MAPKK phosphorylation by Delta MEKK1 were determined by quantifying the amount of 32 P incorporation into purified substrates in a discontinuous assay.
Journal Genes & Dev
Journal Reference v12 i21 p3369 (1998)
Journal Link http://www.genesdev.org/cgi/content/full/12/21/3369
Source Curated
MedLine Reference 12456688:1014
Sentence EXPERIMENTAL PROCEDURES RESULTS DISCUSSION REFERENCES MEKK1 is a MAPK kinase kinase that is activated in response to stimuli that alter the cytoskeleton and cell shape.
Journal J. Biol. Chem
Journal Reference v278 i3 p1403 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/3/1403
Organism plant
Source Curated
MedLine Reference 12651887:1087
Sentence Mos protein functions as a MAPK kinase kinase (MEKK), important for the activation of the MAPK kinase, MEK1 (Nebreda and Hunt 1993 ; Posada et al. 1993 ; Shibuya and Ruderman 1993 ).
Journal Genes & Dev
Journal Reference v17 i6 p683 (2003)
Journal Link http://www.genesdev.org/cgi/content/full/17/6/683
Source Curated
CellType oocyte
MedLine Reference 11337492:1035
Sentence JNK activation by Rac and Cdc42 was shown to be mediated by the mitogen-activated protein kinase kinase kinase MEKK , which phosphorylates the mitogen-activated protein kinase kinase JNKK (also known as SEK1 or MKK4 ( 25-27 )).
Journal J. Biol. Chem
Journal Reference v276 i28 p25876 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/25876
Source Curated
MedLine Reference 10924071:1162
Sentence PKC-mediated activation of the MEKK-SEK-JNK cascade (where MEKK is MAPK kinase kinase that activates SEK, and SEK is MAPK kinase activating JNK) has also been described as a consequence of G protein-coupled receptor activation ( 3 ).
Journal Heart Circul
Journal Reference v279 i2 pH719 (2000)
Journal Link http://ajpheart.physiology.org/cgi/content/full/279/2/H719
Organism Rattus norvegicus
Source Curated
CellType myocyte
MedLine Reference 7721808:1021
Journal J. Biol. Chem
Journal Reference v270 i15 p8984 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/15/8984
Organism mouse
Source Curated
MedLine Reference 12816950:1185
Journal J. Biol. Chem
Journal Reference v278 i35 p32914 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/35/32914
Source Curated
MedLine Reference 11278431:1030
Journal J. Biol. Chem
Journal Reference v276 i14 p10811 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/14/10811
Organism mouse
Source Curated
MedLine Reference 11274055:1032
Journal Genes & Dev
Journal Reference v15 i6 p699 (2001)
Journal Link http://www.genesdev.org/cgi/content/full/15/6/699
Organism plant
Source Curated
MedLine Reference 7614712:1126
Journal Circulation Res
Journal Reference v77 i2 p258 (1995)
Journal Link http://circres.ahajournals.org/cgi/content/full/77/2/258
Organism rat
Source Curated
CellType myocyte
MedLine Reference 11717427:1023
Journal PNAS
Journal Reference v98 i24 p13613 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/24/13613
Source Curated
MedLine Reference 12517717:3
Source Curated
MedLine Reference 9405446:1020
Journal J. Biol. Chem
Journal Reference v272 i51 p32378 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/51/32378
Organism mouse
Source Curated
MedLine Reference 8940179:1008
Journal J. Biol. Chem
Journal Reference v271 i49 p31607 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/49/31607
Organism drosophila
Source Curated
MedLine Reference 12794087:1020
Journal J. Biol. Chem
Journal Reference v278 i34 p32448 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/34/32448
Source Curated
MedLine Reference 11063742:1053
Journal J. Biol. Chem
Journal Reference v276 i7 p4662 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/7/4662
Source Curated
MedLine Reference 8663074:1099
Journal J. Biol. Chem
Journal Reference v271 i23 p13675 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/23/13675
Source Curated
Source Curated
CellType oocyte
MedLine Reference 10805784:1018
Journal PNAS
Journal Reference v97 i10 p5243 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/10/5243
Organism mouse
Source Curated
CellType Embryonic Stem
MedLine Reference 9973483:1197
Journal J. Immunol
Journal Reference v162 i4 p2095 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/162/4/2095
Source Curated
CellType b cell
MedLine Reference 11337489:1032
Journal J. Biol. Chem
Journal Reference v276 i28 p25953 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/28/25953
Organism mouse
Source Curated
MedLine Reference 9890951:1020
Journal J. Biol. Chem
Journal Reference v274 i4 p1957 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/4/1957
Source Curated
MedLine Reference 9341110:1048
Journal J. Biol. Chem
Journal Reference v272 i43 p26815 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/43/26815
Source Curated